摘要
目的探讨β-链蛋白(β-catenin)在宫颈癌中的表达及与手术预后的关系。方法选择行手术治疗的宫颈癌患者72例作为研究对象,取所有患者的病灶组织标本(病灶组)与癌旁组织标本(癌旁组),采用免疫组化法检测β-catenin表达水平,调查患者的病理资料、预后并进行相关性分析。结果病灶组的β-catenin表达阳性率为50.0%,显著高于癌旁组的15.3%(P<0.05)。所有患者都顺利完成手术,随访到2020年4月1日,平均随访时间(16.72±1.28)个月,死亡18例,死亡率为25.0%。不同年龄和不同病理类型宫颈癌患者β-catenin表达阳性率差异无统计学意义(P>0.05);Ⅱ期宫颈癌患者β-catenin表达阳性率显著高于Ⅰ期患者、低分化患者显著高于中低分化患者、预后不良患者显著高于预后良好患者(P<0.05)。β-catenin表达阳性与宫颈癌患者临床分期和预后呈显著正相关,与组织分化程度呈显著负相关(P<0.05)。COX回归分析显示:临床分期、组织学分化、β-catenin表达为影响患者预后死亡的重要因素(P<0.05)。结论β-catenin在宫颈癌中呈现高表达,与患者临床病理特征显著相关,为影响患者手术预后的重要因素。
Objective To explore the expression ofβ-catenin in cervical cancer and its relationship with the prognosis of surgery.Methods 72 cases of patients with cervical cancer who underwent surgical treatment were selected as the research object,and the lesion tissue specimens(lesion group)and para-cancer tissue specimens(para-cancer group)of all patients were collected and given immunohistochemical method to detect the expression level ofβ-catenin,the pathological data,prognosis were recorded and given correlation analysis.Results The positive rates ofβ-catenin expression in the lesion group were 50.0%,which were significantly higher than 15.3%in the paracancerous group(P<0.05).All patients successfully completed the operation and were followed up to April 1,2020,with the average follow-up time were(16.72±1.28)months,there were 18 cases of deaths,and the mortality rate were 25.0%.There was no significant difference in the positive rate ofβ-catenin expression in cervical cancer patients of different ages and different pathological types(P>0.05);The positive rate ofβ-catenin expression in stageⅡcervical cancer patients was significantly higher than that in stageⅠpatients,poorly differentiated patients were significantly higher than poorly differentiated patients,and poor prognosis patients were significantly higher than those with good prognosis(P<0.05).The positive expression ofβ-catenin was significantly positively correlated with the clinical stage and prognosis of cervical cancer patients,and was significantly negatively correlated with the degree of tissue differentiation(P<0.05).COX regression analysis showed that clinical stage,histological differentiation,andβ-catenin expression were important factors affected the prognosis of patients(P<0.05).Conclusionβ-catenin is highly expressed in cervical cancer,which is significantly related to the clinicopathological characteristics of patients,and is an important factor affecting the prognosis of patients after surgery.
作者
宋改让
胡滨
崔金全
SONG Gairang;HU Bin;CUI Jinquan(Luoyang Maternal and Child Health Hospital,Luoyang,471000)
出处
《实用癌症杂志》
2021年第1期32-35,共4页
The Practical Journal of Cancer
基金
河南省医学科技攻关计划项目(编号:201702018)。
关键词
Β-链蛋白
宫颈癌
预后
组织学分化
临床分期
β-chain protein
Cervical cancer
Prognosis
Histological differentiation
Clinical stage
