摘要
目的:观察兰索拉唑胶囊联合枸橼酸铋钾颗粒治疗幽门螺旋杆菌(Hp)阴性十二指肠溃疡的疗效。方法:选取2019年7月—2020年6月于本院接受治疗的60例Hp阴性十二指肠溃疡患者为观察对象,按照随机数字表法分为两组,每组30例。对照组采用兰索拉唑胶囊治疗,观察组采用兰索拉唑胶囊联合枸橼酸铋钾颗粒治疗。比较两组疗效、血常规和肝肾功、不良反应发生率等。结果:治疗2周后,观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗期间两组患者均未出现严重的血常规、肝肾功能异常或其他不良反应,差异无统计学意义(P>0.05)。结论:兰索拉唑胶囊联合枸橼酸铋钾颗粒治疗Hp阴性十二指肠溃疡疗效确切,能促进溃疡面愈合,且对患者血常规、肝肾功能影响较小,具有较高的安全性。
Objective:To observe the efficacy of lansoprazole capsule combined with Bismuth Potassium Citrate Granules in the treatment of Helicobacter pylori(Hp)negative duodenal ulcer.Methods:60 patients with Hp negative duodenal ulcer who were treated in our hospital from July 2019 to June 2020 were selected as the research objects and randomly divided into two groups,30 cases in each group.The control group was treated with lansoprazole capsules,and the observation group was treated with lansoprazole capsules combined with Bismuth Potassium Citrate Granules.The curative effect,blood routine,abnormal liver and kidney function and the incidence of adverse reactions were compared between the two groups.Results:After 2 weeks of treatment,the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05);during the treatment,no serious blood routine,liver and kidney dysfunction or other adverse reactions occurred in the two groups,the difference was not statistically significant(P>0.05).Conclusion:Lansoprazole capsule combined with Bismuth Potassium Citrate Granules has definite curative effect in the treatment of Hp negative duodenal ulcer,can promote the healing of ulcer surface,and has little effect on blood routine,liver and kidney function,so it has high safety.
作者
彭学铭
吴霞
PENG Xueming;WU Xia(The Second Affiliated Hospital of Yichun University,Yichun Jiangxi 336000,China;Yichun Traditional Chinese Medicine Hospital,Yichun Jiangxi 336000,China)
出处
《药品评价》
CAS
2020年第23期41-42,48,共3页
Drug Evaluation
关键词
十二指肠溃疡
幽门螺旋杆菌
兰索拉
枸橼酸铋钾
Duodenal Ulcer
Helicobacter Pylori
Lansoprazole
Bismuth Potassium Citrate
