摘要
目的:了解贵州省人民医院2018年临床分离株对常用抗菌药物的耐药性.方法:采用自动化仪器MIC法,纸片扩散法(K-B法)和E-Test法对临床分离株进行药敏试验,并按美国临床和实验室标准化协会(CLSI)2017年标准判断药敏试验结果,数据分析采用WHONET5.6软件,对2018年细菌耐药资料作回顾性调查分析.结果:2018年共收集非重复分离菌8534株,革兰阴性菌为67.8%(5784/8534),革兰阳性菌33.2%(2750/8534).排名前三的细菌分别为大肠埃希氏菌,肺炎克雷伯氏菌,金黄色葡萄球菌.其中分离出耐甲氧西林金黄色葡萄球菌(MRSA)308株,检出率为37%(308/834);大肠埃希菌,肺炎克雷伯菌对亚胺培南的耐药率分别为1.2%,18.5%;铜绿假单胞菌对亚胺培南的耐药率分别为22.1%;鲍曼不动杆菌对亚胺培南的耐药率分别为64.4%.结论:对细菌耐药性进行长期监测有助于了解我院细菌耐药性的变迁,为临床合理用药提供依据.
Objective:To investigate the antibiotic resistance of clinical bacteria obtained from hospital in Guizhou.Methods:Bacterial susceptibility tests were performed by using MIC、KB or E-Test methods.Results were analyzed according to CLSI 2017.All data were analyzed by WHONET5.6 sofeware.Results:Of the 8534 clinical isolates 67.8%(5784/8534)were Gram negative bacteria,33.2%(2750/8534)were Gram positive bacteria.The detection rate of meth ici Uin-resistant Staphylococcus aureus was 37.0%.There were 1.2%and 18.5%of E.coli andKlebsieUa pneumonia resistant to imipenem,22.1%of P.areuginosa and 64.4%of Acinetobacter baumanii resistant to imipenem.Con Clusi on:Regular surveillance of antimicrobial resistance in clinical isolates is important to understand the trend of antimicrobial resistance and will provide a theoretical basis for rational antimicrobial therapy.
作者
胡方芳
张华
罗湘蓉
李红凌
卢志顺
HU Fang-fang;ZHANG Hua;LUO Xiang-rong(Guizhou Provinclal people's Hospital,Guizhou Guiyang 550001)
出处
《医学检验与临床》
2021年第1期16-20,共5页
Medical Laboratory Science and Clinics
基金
贵州省人民医院青年基金项目(GZSYQN[2016]15号)。
关键词
细菌耐药
药敏实验
耐药监测
Surveillance ofbacterial resistance
Antimicrobial agents
Bacterial resistance
