摘要
目的探讨消癌平片联合常规化疗方案对Ⅲ-Ⅳ期胃癌患者血清转化生长因子-α(TGF-α)、血管内皮生长因子(VEGF)水平的影响。方法选取2019年1月至2020年5月无锡市锡山人民医院治疗的60例Ⅲ-Ⅳ期胃癌患者作为研究对象,按照随机数字法分为试验组和常规组,各30例。比较两组患者的治疗效果、治疗前后生存质量评分(KPS)、疼痛评分(VAS)及血清TGF-α、VEGF水平。结果试验组患者近期治疗有效率为90.00%,高于常规组的70.00%(P<0.05);干预后试验组KPS评分、VAS评分及血清TGF-α、VEGF水平均优于常规组(P<0.05);关于毒副反应情况,两组无显著差异(P>0.05);关于中、重度毒性反应发生情况,试验组白细胞减少及血红蛋白下降均为0例,对照组分别为16.67%及6.67%,试验组显著低于对照组(P<0.05)。结论消癌平片联合常规化疗方案可有效控制Ⅲ-Ⅳ期胃癌患者的病情进展,提高其治疗效果,值得临床应用推广。
Objective To investigate the effect of xiaoaiping tablets combined with conventional chemotherapy on TGF-αand VEGF in patients with stageⅢ-Ⅳgastric cancer.Methods Choose from January 2019 to May 2020,60 patients with stageⅢ-Ⅳgastric cancer treated in Wuxi Xishan People's Hospital were taken as the research objects,according to the method of random numbers are divided into experimental group and routine group,30 cases each.The treatment effect,quality of life(KPS score),VAS pain score,serum TGF-αand VEGF levels before and after treatment were compared between the two groups.Results The short-term effective rate of the experimental group was 90.00%,which was higher than that of the conventional group(70.00%,P<0.05).KPS score,VAS score,serum TGF-αand VEGF in experimental group were better than those in routine group(P<0.05).Regarding the toxicity profile,there were no significant differences between the two groups(P>0.05);with regard to moderate and severe toxic reactions,leukopenia and hemoglobin decrease in the experimental group were 0 case,while those in the control group were 16.67%and 6.67%respectively,which were lower in the experimental group than those in the control group(P<0.05).Conclusion Xiaoaiping tablets combined with conventional chemotherapy can effectively control the progression of stageⅢ-Ⅳgastric cancer and improve the therapeutic effect,which is worth popularizing.
作者
强金虎
张世强
孟芳
邓晓兰
QIANG Jinhu;ZHANG Shiqiang;MENG Fang;DENG Xiaolan(Wuxi Xishan People's Hospital,Wuxi,Jiangsu 214000,China)
出处
《大医生》
2020年第21期36-38,共3页
Doctor
关键词
消癌平片
胃癌
化疗
KPS评分
VAS疼痛评分
xiaoaiping tablets
gastric cancer
chemotherapy
KPS score
VAS pain score
