摘要
细胞周期蛋白B1(cyclin B1,CCNB1)在调节细胞周期的G2/M期进展中起关键作用。越来越多的研究证实CCNB1在多种恶性肿瘤中表达,并参与肿瘤细胞的生长、分化、凋亡和转移。CCNB1在不同类型的肿瘤中存在差异性表达,其表达的变化影响肿瘤的发展、治疗及预后。本文综合近年来国内外的研究,对CCNB1在肿瘤的研究进展作一综述。
Cyclin B1(CCNB1)plays a key role in regulating the G2/M phase of the cell cycle and studies gradually have shown that CCNB1 is expressed in many malignant tumors and participates in the growth,differentiation,apoptosis and metastasis of tumor cells.CCNB1 is differentially expressed in different types of tumors,and its expression changes affect the development,treatment and prognosis of tumors.In this paper,the research progress of CCNB1 in tumor at home and abroad was reviewed.
作者
冷远秀
徐林
陈芳
罗清
Leng Yuanxiu;Xu Lin;Chen Fang;Luo Qing(Department of Oncology,Affiliated Hospital of Zunyi Medical University)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2021年第1期1-4,共4页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:81260397、81860469)
贵州省肿瘤学研究生工作站资助项目(编号:黔教研合GZZ字〔2016〕06)
贵州省科技厅联合基金资助项目(黔科合LH号〔2015〕7485)。
