摘要
大环内酯类抗生素在水产养殖过程中广泛使用,如果使用不当会造成药物残留,危害人体健康。当前对大环内酯类药物残留的监控日益受到重视,本文主要介绍水产品中大环内酯类药物残留测定采用各种的样品前处理和检测方法,并分析比较薄层色谱法(thin layer chromatography, TLC)、紫外分光光度法、微生物效价法、气相色谱-质谱法(gas chromatography mass spectrometry, GC-MS)、高效液相色谱法(high performance liquid chromatography, HPLC)、液相色谱-质谱法(liquid chromatography mass spectrometry, LC-MS/MS)等几种检测方法的优劣,研究认为采用HPLC和LC-MS/MS法检测大环内酯类药物残留,能够很好地满足标准限量的要求。
Macrolide antibiotics are widely used in aquaculture. Drug residues and human health damage could be caused by inappropriate use of macrolide antibiotics. More attention has been paid to the monitoring of macrolide residues nowadays. This paper mainly introduced the determination of macrolide residues in aquatic products by various sample pretreatment and determine methods, and analyzed and compared the advantages and disadvantages of thin layer chromatography, ultraviolet spectrophotometry, microbial titer, gas chromatography mass spectrometry, high performance liquid chromatography(HPLC) and liquid chromatography-mass spectrometry(LC-MS/MS). It was considered that HPLC and LC-MS/MS can satisfy the requirements of standard limit for the determination of macrolide residues.
作者
梁敏
章雪琴
LIANG Min;ZHANG Xue-Qin(Yunfu Institute of Food and Drug Inspection,Yunfu 527300,China;Wuhan Omega Biomedicine Co.,LTD.,Wuhan 430070,China)
出处
《食品安全质量检测学报》
CAS
北大核心
2021年第2期595-601,共7页
Journal of Food Safety and Quality
关键词
水产品
大环内酯类
药物残留
检测方法
aquatic product
macrolide antibiotics
drug residues
detection method
