摘要
在最新发布的全球癌症报告中,乳腺癌发病率呈现逐年升高的趋势,跃居女性癌症发病率第一位,乳腺癌的防治成为重中之重。其发生受多种因素的影响,近年随着人类基因组计划的完成,肠道菌群相关基因被发现与多种疾病发生发展相关,并通过影响雌激素水平、免疫功能、乳房局部组织菌群等过程参与乳腺癌的多个病理过程,本文就近几年国内外文献探讨肠道菌群与乳腺癌之间的相关性及机制进行总结并作一综述,深入认识二者间联系,以制定新的乳腺癌防治策略。
In the latest global cancer statistics,the incidence of breast cancer is increasing year by year,and is ranking first in the incidence of breast cancer.The prevention and treatment has become important.Occurrence of breast cancer is affected by many factors.In recent years,with the completion of the human genome project,gut microbiota-related genes have been found to be involved in the development of various diseases,and participate in many pathological processes of breast cancer by affecting estrogen levels,immune function,and the microbiota of local tissue of the breast.In recent years,domestic and foreign literatures have explored the correlation and mechanism between intestinal flora and breast cancer,and have in-depth understanding of the relationship between the them.However,due to the many influencing factors of breast cancer,large-scale experiments are still needed to observe and verify to develop a new breast cancer prevention strategy.
作者
董阿茹汗
张莹
DONG Aruhan;ZHANG Ying(The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
出处
《现代肿瘤医学》
CAS
北大核心
2021年第3期539-542,共4页
Journal of Modern Oncology
关键词
乳腺癌
肠道菌群
机制
breast cancer
intestinal microbiota
pathogenic mechanisms
