摘要
目的:探究免疫性肠内营养支持对食管癌化疗患者临床疗效及生活质量的影响。方法:回顾性选取2017年5月至2019年6月于我院确诊为食管癌并接受紫杉醇+顺铂(TP)化疗的83例符合研究纳排标准的患者资料。根据化疗期间采取营养支持治疗方式不同,将39例行常规肠外营养支持的患者列为肠外支持组(TPN组),44例行免疫型肠内营养支持的患者列为免疫型肠内支持组(IMN组)。对比评估免疫性肠内营养支持对食管癌化疗患者临床疗效、毒性反应、营养状态及生活质量的影响。结果:IMN组临床治疗总有效率显著高于TPN组(59.1%vs 38.5%),差异有统计学意义(P<0.05)。IMN组Ш度以上毒性反应的比率小于TPN组,差异有统计学意义(P<0.05)。治疗后TPN组各营养指标水平较治疗前显著降低,IMN组各营养指标水平明显高于TPN组,差异有统计学意义(P<0.05)。IMN组总体健康评分和功能领域评分高于TPN组,症状领域评分低于TPN组,生活质量整体状况优于TPN组,差异有统计学意义(P<0.05)。结论:免疫型肠内营养支持可有效改善食管癌化疗患者营养状况,降低毒性反应发生率,提高患者生活质量和临床疗效。
Objective:To investigate the effect of immunological enteral nutrition support on clinical efficacy and quality of life in patients with esophageal cancer undergoing chemotherapy.Methods:Data of 83 patients who were diagnosed with esophageal cancer and received paclitaxel+cisplatin(TP)chemotherapy in our hospital from May 2017 to June 2019 and met the study's nano-exclusion criteria were retrospectively selected.Depending on the type of nutritional support used during chemotherapy,thirty-nine patients with routine parenteral nutrition support were classified as parenteral nutrition support(TPN group),44 patients receiving immune enteral nutrition support were classified as immune enteral nutrition support group(IMN group).The effects of immunological enteral nutrition support on clinical efficacy,toxicity,nutritional status and quality of life in patients with chemotherapy for esophageal cancer were evaluated.Results:The total clinical effective rate of the IMN group(59.1%vs 38.5%)was significantly higher than that of the TPN group(P<0.05).Toxic reaction rate aboveШdegrees in IMN group was less than TPN group,and the difference was statistically significant(P<0.05).After treatment,the levels of nutritional indicators in the TPN group were significantly lower than those before treatment,while those in the IMN group were significantly higher than those in the TPN group,with statistically significant differences(P<0.05).The overall health score and functional area score of the IMN group were higher than that of the TPN group,while the symptom area score was lower than that of the TPN group,and the overall quality of life was better than that of the TPN group,with statistically significant differences(P<0.05).Conclusion:Immune enteral nutrition support can effectively improve the nutritional status of patients undergoing chemotherapy for esophageal cancer,reduce the incidence of toxic reactions,and improve the quality of life and clinical efficacy of patients.
作者
邹晓影
杨长婷
姜桂春
ZOU Xiaoying;YANG Changting;JIANG Guichun(Liaoning Cancer Hospital,Liaoning Shenyang 110042,China)
出处
《现代肿瘤医学》
CAS
北大核心
2021年第4期595-599,共5页
Journal of Modern Oncology
基金
辽宁省自然科学基金(编号:20180550229)。
关键词
免疫型肠内营养支持
食管癌
TP化疗
临床效果
生活质量
immune enteral nutrition support
esophageal cancer
TP chemotherapy
clinical effect
quality of life
