摘要
目的探讨体重指数对多囊卵巢综合征患者行IVF/ICSI-ET辅助生殖治疗后妊娠结局的影响。方法回顾性分析2017年1月-2019年12月在新疆佳音医院生殖医学中心接受IVF/ICSI-ET辅助生殖治疗的多囊卵巢综合征患者共186个周期,根据体重指数将周期分为:超重组(BMI≥25.0 kg/cm2),正常组(BMI <25.0 kg/cm2),分析两组在助孕周期中的相关实验室指标及临床妊娠结局。结果超重组的基础睾酮T值明显高于正常组(2.95±1.00 VS 1.64±0.72,P <0.05);Gn天数和Gn总量明显高于正常组(13.05±4.12 VS 10.33±2.25,2919.20±1118.05 VS 1889.05±771.27,P <0.05),hCG日的血清E2水偏低(9970.20±5672.82 VS 17998.15±17562.27,P<0.05),获卵数低(13.85±9.00 VS 24.38±10.90,P <0.05),平均获卵数和平均移植胚胎数要明显低于正常组(13.85±9.00 VS 24.38±10.90,1.98±0.21 VS 2.05±0.32,P <0.05),胚胎种植率和临床妊娠率明显低于正常组(23.83%VS 40.88,36.11%VS 59.00%,P <0.05),活胎分娩率也低于正常组(35.19%VS 52.56%,P <0.05)。结论肥胖的PCOS女性的卵巢对药物的反应性差,从而导致卵子质量下降,进一步优质胚胎数目下降,最终导致胚胎种植率和临床妊娠率下降,因此肥胖可能是导致PCOS患者不良妊娠结局的主要原因。
Objective To investigate the effect of body mass index(bmi)on pregnancy outcomes after IVF/ICSI-ET assisted reproduction in patients with polycystic ovary syndrome(PCOS). Methods A total of 186 cycles of PCOS patients who received IVF/ICSI-ET assisted reproductive therapy in a reproductive medicine center from January 2017 to December 2019 were retrospectively analyzed. According to body mass index, the cycles were divided into the overweight group(BMI≥25.0 kg/cm2)and the normal group(BMI < 25.0 kg/cm2). The related laboratory indexes and clinical pregnancy outcomes of the two groups were analyzed. Results The basal testosterone t value of the super recombinant group was significantly higher than that of the normal group(2.95 ± 1.00 vs 1.64 ±0.72,P < 0.05), the days of GN and the total amount of GN were significantly higher than that of the normal group(13.05 ± 4.12 vs10.33 ± 2.25,2919.20 ± 1118.05 vs 1889.05 ± 771.27,P < 0.05), the serum E2 level on hCG day was low(9970.20 ± 5672.82 vs17998.15 ± 17562.27,P<0.05), and the number of oocytes obtained was low(13.85 ± 9.00 vs 24.38 ± 10.90,P < 0.05)The average number of retrieved eggs and transferred embryos were significantly lower than that of the normal group(13.85 ± 9.00 vs 24.38 ±10.90,1.98 ± 0.21 vs 2.05 ± 0.32,P < 0.05). The implantation rate and clinical pregnancy rate were significantly lower than that of the normal group(23.83% vs 40.88,36.11% vs 59.00%,P < 0.05). The live birth rate was also lower than that of the normal group(35.19% vs 52.56%,P < 0.05). Conclusions Obese PCOS women ovaries have poor response to drugs, which leads to the decline of egg quality, the further decline of the number of high-quality embryos, and ultimately the decline of embryo implantation rate and clinical pregnancy rate. Therefore, obesity may be the main cause of adverse pregnancy outcomes in PCOS patients.
作者
宋琴
马玲玲
SONG Qin;MA Lingling(Reproductive Medicine Center of Xinjiang Jiayin Hospital,Urumqi,830000,China)
出处
《新疆医学》
2021年第1期52-55,共4页
Xinjiang Medical Journal
