摘要
目的了解血脂异常与非酒精性脂肪肝(NAFLD)发病的关系,为NAFLD的预防控制提供参考依据。方法采取前瞻性队列研究,于2014年1—12月采用方便抽样方法在天津市第一中心医院健康管理科抽取2658名非NAFLD体检者进行随访调查,分析血脂异常与NAFLD发病的关系。结果2658名非NAFLD体检者在4年中共发生NAFLD 875例,发病密度为83/1000人年;在调整了年龄、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、谷丙转氨酶(ALT)、尿酸(UA)、空腹血糖(FPG)和血脂谱指标后,多因素Cox比例风险回归分析结果显示,基线甘油三酯(TG)水平较高(HR=1.324,95%CI=1.083~1.617)和低密度脂蛋白胆固醇(LDL-C)水平较高(HR=1.232,95%CI=1.030~1.474)均可增加男性NAFLD的发病风险;基线TG水平较高(HR=1.589,95%CI=1.078~2.344)可增加女性NAFLD的发病风险。结论血脂异常与NAFLD发病有关,防止TG和LDL-C水平升高可能是预防和控制NAFLD发生的有效措施之一。
Objective To investigate the correlation between dyslipidemia and nonalcoholic fatty liver disease(NAFLD)and to provide references for the prevention and control of NAFLD.Methods Using convenient sampling,we recruited2658 physical examinees(mean age=41.98±13.99,53.3%males)without NAFLD at the First Central Hospital of Tianjin Municipality from January through December 2014.A follow-up survey was conducted among all the participants during2018 and the correlation between baseline dyslipidemia and the incidence of NAFLD was analyzed.Results By the end of follow-up in 2018,totally 875 NAFLD patients were identified among the all participants,with an incidence density of83/1000 person-years.The results of multivariate Cox proportional hazard risk(HR)regression analysis revealed that high baseline serum triglyceride(TG)(HR=1.324,95%confidence interval[95%CI]:1.083–1.617)and low-density lipoprotein cholesterol(LDL-C)(HR=1.232,95%CI:1.030–1.474)could increase the incidence of NAFLD in males and high serum TG increase the incidence of NAFLD in females after adjusting for age,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),alanine aminotransferase(ALT),uric acid(UA),fasting plasma glucose(FPG)and blood lipid profiles.Conclusion Dyslipidemia is associated with NAFLD incidence and the prevention of elevated serum TG and LDL-C might be one of effective measures for the prevention and control of NAFLD.
作者
郭奕瑞
张莉
GUO Yi-rui;ZHANG Li(Health Management Department,Tianjin First Central Hospital,Tianjin 300192,China)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2021年第1期141-144,共4页
Chinese Journal of Public Health
