摘要
目的探讨七氟醚和丙泊酚对腹腔镜子宫肌瘤剔除术患者炎症因子及应激反应的影响。方法选取2016年5月至2019年5月于天长市中医院就诊收治的78例腹腔镜子宫肌瘤剔除术患者为研究对象,随机抽样法分为观察组、对照组(各39例)。对照组给予静脉输注丙泊酚麻醉药物,观察组给予吸入七氟醚麻醉药物。对比两组患者麻醉效果、(T0、T1、T2)时间段应激反应、炎症因子(TNF-α、IL-1β)指标水平及不良反应发生情况。结果两组患者麻醉时间比较无统计学意义(P>0.05),观察组患者睁眼时间、自主呼吸恢复时间、言语应答时间、定向力恢复时间、拔管时间明显短于对照组(P<0.05);两组患者T0时间段HR、MAP指标水平比较无统计学意义(P>0.05),观察组T1、T2时间段GLU、COR、AngⅡ水平低于对照组(P<0.05);观察组T1、T2时间段TNF-α、IL-1β指标水平显著低于对照组(P<0.05);观察组不良反应发生率与对照组比较无统计学意义(P>0.05)。结论七氟醚药物较丙泊酚在腹腔镜子宫肌瘤剔除术中的麻醉效果更好,能有效抑制手术中应激反应,降低炎症因子,且安全性更高。
Objective To investigate the effects of sevoflurane and propofol on inflammatory factors and stress response in patients undergoing laparoscopic myomectomy.Methods 78 patients with laparoscopic myomectomy were enrolled in our hospital from May 2016 to May 2019.They were randomly divided into observation group and control group(39 cases each).The control group was given an intravenous infusion of propofol anesthetic,and the observation group was given an inhaled sevoflurane anesthetic.The anesthetic effect,stress response(T0,T1,T2),inflammatory factor(TNF-α,IL-1β)index and adverse reaction rate were compared between the two groups.Results There was no significant difference in anesthesia time between the two groups(P>0.05).The blink time,spontaneous breathing recovery time,speech response time,orientation recovery time,and extubation time were significantly shorter in the observation group than in the control group(P<0.05).There were no significant differences in HR and MAP levels between the two groups(P>0.05).The levels of GLU,COR and AngII in the T1 and T2 time groups were lower than those in the control group(P<0.05).The observation groups T1 and T2 The levels of TNF-αand IL-1βwere significantly lower than those of the control group(P<0.05).The incidence of adverse reactions in the observation group was not significantly different from that of the control group(P>0.05).Conclusion Compared with propofol,sevoflurane has better anesthesia in laparoscopic myomectomy,can effectively inhibit the stress response during surgery,reduce inflammatory factors,and is safer.
作者
沈寿祥
王思亮
曹大徽
SHEN Shou-xiang;WANG Si-liang;CAO Da-hui(Department of Anesthesiology.Tianchang Hospital of Traditional Chinese Med icine 239300,China)
出处
《中国实验诊断学》
2021年第1期57-60,共4页
Chinese Journal of Laboratory Diagnosis
基金
安徽省卫生厅医药科研计划项目(1298TC20173B03)。
