摘要
目的:探讨高危型人乳头瘤病毒数据库建立与宫颈病变的预防临床研究。方法:选择2018年6月至2019年12月本院妇科门诊就诊的宫颈病变病例76例作为对象,完成液基薄层细胞学(TCT)检查,建立高危型人乳头瘤病毒(HPV)的检测与数据库,根据TCT检查结果异常和HPV检查证实为单一高危型HPV感染的,行电子阴道镜及宫颈活检术的为观察组;根据TBS诊断系统,TCT结果异常,HPV结果阴性,行电子阴道镜及宫颈活检术的为对照组。根据上述分组,研究注射HPV疫苗与未注射HPV疫苗与宫颈疾病之间的关系。结果:观察组与对照组宫颈活检次数、孕次、产次、绝经时间等资料比较无显著差异(P>0.05);实验组患者中低度鳞状上皮内病变(LSIL)患者17例、高度鳞状上皮内病变(HSIL)患者9例,宫颈癌(CC)患者5例。观察组与对照组LSIL病例数无统计学意义(P>0.05);观察组HSIL及CC病例数低于对照组(P<0.05)。结论:建立高危型人乳头瘤病毒数据库,将高危型HPV研究系列化,能追踪研究高危型HPV各个亚型与变异,能预测疾病发生率;通过数据库能明确高危型HPV与宫颈病变的关系,能为高危型PHV疫苗的使用提供依据和参考。
Objective:To explore the establishment of a high-risk human papillomavirus database and the clinical study on the prevention of cervical lesions.Methods:Select 76 cases of cervical lesions from our gynecological clinic from June 2018 to December2019 as subjects,complete the TCT examination,establish a high-risk HPV detection and database,and confirm that it is single based on the abnormal results of the TCT examination and HPV examination.For high-risk HPV infections,those who underwent electronic colposcope and cervical biopsy were the observation group;according to the TBS diagnostic system,TCT results were abnormal and HPV results were negative.Those who underwent electronic colposcope and cervical biopsy were the control group.Based on the above groupings,the relationship between HPV vaccine injection and non-HPV vaccine injection and cervical disease was studied.Results:There were no significant differences in the number of cervical biopsies,pregnancy,parity,and menopause time between the observation group and the control group(P>0.05).Among the patients in the experimental group,17 were LSIL patients,9 were HSIL patients,and 5 were CC patients.The number of LSIL cases in the observation group and the control group was not statistically significant(P>0.05);the number of HSIL and CC cases in the observation group was lower than that in the control group(P<0.05).Conclusion:The establishment of a database of high-risk human papillomavirus,and serialization of high-risk HPV research,can track and study various subtypes and variations of high-risk HPV,and can predict the incidence of disease;the database can clarify the relationship between high-risk HPV and cervical lesions,It can provide basis and reference for the use of high-risk PHV vaccine.
作者
李杏婵
何雅婷
赵愚
Li Xingchan(Southeast Central Hospital of Dongguan City,Dongguan Guangdong 523000)
出处
《黑龙江医药》
CAS
2021年第1期25-27,共3页
Heilongjiang Medicine journal
基金
2019年东莞市社会科技发展一般项目立项(立项编号:201950715032858)。
