摘要
目的研究C1q/肿瘤坏子因子相关蛋白3(CTRP3)、C1q/肿瘤坏子因子相关蛋白9(CTRP9)水平及血管钙化率在糖尿病肾病患者中的表达情况,并探讨三者之间的关系以及对疾病发展程度影响。方法选取糖尿病肾病患者135例(患者组)为研究对象,同时另选取60例健康志愿者为对照组,通过实验室常规指标检查及X线片检查,分析受试者的基本临床资料与血管钙化情况,酶联免疫法测定糖尿病肾病患者血清CTRP3、CTRP9水平,分析糖尿病肾病患者血清CTRP3、CTRP9水平与血管钙化的关系。结果患者组Alb值显著低于对照组,患者组FPG值、CRP值、血磷值及血钙磷乘积值显著高于对照组(P<0.05)。患者组的血管钙化率显著高于对照组(P<0.05)。患者组血清CTRP3水平和血管钙化率显著高于对照组(P<0.05),CTRP9水平显著低于对照组(P<0.05)。CTRP3水平与患者年龄、病程长短、临床分期、24 h尿微量清蛋白排泄率及血管钙化率显著相关(P<0.05);CTRP9水平与患者病程长短、临床分期、24 h尿微量清蛋白排泄率及血管钙化率显著相关(P<0.05)。血清CTRP3、CTRP9水平是影响糖尿病肾病患者血管钙化的独立危险因素(P<0.05)。结论CTRP3在糖尿病肾病患者血清中高表达,CTRP9低表达,与病程、临床分期、24 h尿微量清蛋白排泄率及血管钙化有关,是影响血管钙化的独立危险因素。
Objective To investigate the expression levels of C1q/tumor necrosis factor-related protein 3(CTRP3),C1q/tumor necrosis factor-related protein(CTRP9)and vascular calcification rate in patients with diabetic nephropathy as well as the correlation among the three indexes,and to explore their effects on the degree of disease development.Methods A total of 135 patients with diabetic nephropathy were enrolled as research group,at the same time,the other 60 healthy subjects were enrolled as control group.Routine laboratory examination and X-ray examination were used to analyze the basic clinical data and vascular calcification status of the subjects.Moreover,enzyme linked immunosorbent assay(ELISA)was used to detect the serum levels of CTRP3 and CTRP9 of the patients,and to analyze the correlation between the serum levels of CTRP3,CTRP9 and vascular calcification.Results The Alb value in reaesrch group was significantly lower than that in control group(P<0.05),however,the FPG value,CRP value,blood phosphorus value and blood calcium phosphorus product value were significantly higher than those in control group(P<0.05).Moreover the serum levels of CTRP3 and vascular calcification rate in research group were significantly higher than those in control group(P<0.05),but the serum levels of CTRP9 in research group were significantly lower than those in control group(P<0.05).Furthermore,the serum levels of CTRP3 were closely correlated with patient’s age,course of disease,clinical stage,24h urinary microalbumin excretion rate and vascular calcification rate(P<0.05),moreover,the serum levels of CTRP9 were closely correlated with course of disease,clinical stage,24h urinary microalbumin excretion rate and vascular calcification rate(P<0.05).In addition the serum levels of CTRP3 and CTRP9 were independent risk factors for vascular calcification in patients with diabetic nephropathy(P<0.05).Conclusion The expression levels of serum CTRP3 are increased,and the expression levels of serum CTRP9 were decreased in patients with diabetic nephropathy,which are related to the course of disease,clinical stage,24h urinary microalbumin excretion rate and vascular calcification,and which are independent risk factors affecting vascular calcification of patients.
作者
杨会娜
王莉
陆靖
谭文彬
YANG Huina;WANG Li;LU Jing(Department of Clinical Laboratory,The First People’s Hospital of Ji’ning City,Shandong,Ji’ning 272011,China;不详)
出处
《河北医药》
CAS
2021年第1期67-70,共4页
Hebei Medical Journal
基金
山东省医药卫生科技发展计划项目(编号:2017WS0193)。
