摘要
咖啡酰奎宁酸类化合物是植物体内重要的次生代谢产物,具有抗氧化,抗菌消炎,抗肿瘤,抗病毒,调节血糖、血脂、血压以及保肝等多种生物活性,但存在口服生物利用度较低的问题。本文综述了咖啡酰奎宁酸类化合物生物活性的研究进展,以及制备纳米颗粒包封物、脂质体制剂、磷脂复合物、乳液运载体系和环糊精包埋等提高生物利用度的技术方法,以期为咖啡酰奎宁酸类化合物的研究及资源的合理开发利用提供理论依据。
Caffeoylquinic acids are major plant secondary metabolites with many biological activities such as antioxidant,antibacterial,anti-inflammatory,anti-tumor,anti-viral,blood glucose-regulatory,blood lipid-regulatory,blood pressure-regulatory,and hepatoprotective effects.However,they have low oral bioavailability.In this review,we summarize recent advances in the biological activity of caffeoylquinic acids and the technologies for improving their bioavailability such as nanoparticle encapsulation,liposome preparations,phospholipid complexes,emulsion delivery systems and cyclodextrin inclusion,in order to provide a theoretical basis for studies on caffeoylquinic acids and rational development and utilization of this resource.
作者
朱文卿
任汉书
徐美霞
朱姗姗
郑振佳
陈伟
ZHU Wenqing;REN Hanshu;XU Meixia;ZHU Shanshan;ZHENG Zhenjia;CHEN Wei(Key Laboratory of Food Processing Technology and Quality Control in Shandong Province,College of Food Science and Engineering,Shandong Agricultural University,Tai’an 271018,China;Guangrao Traditional Chinese Medicine Hospital,Dongying 370523,China;Chinese Academy of Inspection and Quarantine,Beijing 100176,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2021年第3期321-329,共9页
Food Science
基金
山东省自然科学基金项目(ZR2019BC100)
烟台市重点研发计划项目(2018ZDCX014)
泰山产业领军人才工程高效生态农业创新类计划项目(LJNY201705)
山东省高等学校食品安全与营养健康创新团队发展计划项目。
关键词
咖啡酰奎宁酸
生物活性
利用度
caffeoylquinic acid
biological activities
utilization
