摘要
目的探讨对抑郁症患者采用文拉法辛与艾司西酞普兰治疗的疗效差异。方法选择该院2017年1月—2019年12月收治的抑郁症患者76例,按照随机数表法分为采用文拉法辛缓释片治疗对照组(n=38)与采用艾司西酞普兰治疗实验组(n=38),对比临床疗效、治疗后各时段(治疗1、2、4、6周末)汉密尔顿抑郁(HAMD)评分、不良反应情况及药物经济学指标。结果实验组治疗总有效率为92.11%(35/38),对照组总有效率89.47%(34/38),差异无统计学意义(χ^2=0.000,P>0.05)。治疗1、2周末实验组HAMD评分分别为(18.40±3.28)分、(13.57±3.12)分,低于对照组(20.27±4.33)分、(15.80±4.26)分,差异有统计学意义(t=2.122、2.603,P<0.05)。治疗4、6周末实验组HAMD评分分别为(11.54±4.03)分、(7.99±4.26)分,对照组分别为(11.65±4.11)分、(8.21±3.85)分,差异无统计学意义(t=0.118、0.236,P>0.05)。实验组用药期间不良反应为26.32%(10/38),低于对照组50.00%(19/38),差异有统计学意义(χ^2=4.517,P<0.05)。实验组药物经济学指标成本/效果为(7.83±1.02)元/%,高于对照组(1.51±0.38)元/%,差异有统计学意义(t=35.792,P<0.05)。结论采用文拉法辛与艾司西酞普兰治疗抑郁症的疗效相当,艾司西酞普兰用药安全性更高,起效更为迅速,文拉法辛的药物经济学指标更好,应结合临床需求合理选择用药。
Objective To investigate the difference in curative effect between venlafaxine and escitalopram in the treatment of depression patients.Methods A total of 76 patients with depression in the hospital from January 2017 to December 2019 were selected for diagnosis and treatment.According to the random number table,they were divided into a control group(n=38)treated with venlafaxine sustained-release tablets and escitalopram treatment experimental group(n=38),the clinical efficacy,the Hamilton Depression(HAMD)scores in each period after treatment(treatment 1,2,4,and 6 weekends),adverse reactions and pharmacoeconomic indicators.Results The total effective rate of treatment in the experimental group was 92.11%(35/38),and the total effective rate in the control group was 89.47%(34/38),the difference was not statistically significant(χ^2=0.000,P>0.05).The HAMD scores of the experimental group were(18.40±3.28)points and(13.57±3.12)points respectively,which were lower than those of the control group(20.27±4.33)points and(15.80±4.26)points,the difference was statistically significant(t=2.122,2.603,P<0.05).The HAMD scores of the experimental group were(11.54±4.03)points and(7.99±4.26)points,respectively,and the control group were(11.65±4.11)points and(8.21±3.85)points,the difference was not statistically significant(t=0.118,0.236,P>0.05).The adverse reaction during the treatment of the experimental group was 26.32%(10/38),lower than the control group 50.00%(19/38),the difference was statistically significant(χ^2=4.517,P<0.05).The pharmacoeconomic index cost/effect of the experimental group was(7.83±1.02)yuan/%,which was higher than the control group(1.51±0.38)yuan/%,the difference was statistically significant(t=35.792,P<0.05).Conclusion The efficacy of venlafaxine and escitalopram in the treatment of depression is equivalent.Escitalopram is safer and has a faster onset of action.Venlafaxine has better pharmacoeconomic indicators and should be combined reasonable choice of drugs for clinical needs.
作者
冯承雨
FENG Cheng-yu(Department of Psychiatry,Jining Rongfu Military Hospital,Jining,Shandong Province,272100 China)
出处
《世界复合医学》
2020年第12期9-11,共3页
World Journal of Complex Medicine
