摘要
目的研究甲巯咪唑联合普萘洛尔治疗甲状腺功能亢进的效果及对患者肝功能的影响。方法抽取2018年5月至2019年5月平煤神马医疗集团总医院收治的95例甲亢患者作为研究对象,随机分为对照组(甲巯咪唑治疗)46例和观察组(对照组基础上服用普萘洛尔治疗)49例。比较治疗前后两组患者甲状腺激素、肝功能指标以及生化指标水平,评价两组临床疗效、不良反应与复发情况。结果观察组临床有效率高于对照组(P<0.05);治疗后两组游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺受体抗体(TRAb)水平低于治疗前,且观察组改善程度优于对照组(P<0.05);治疗后两组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、血清总胆红素(TBIL)水平低于治疗前,且观察组降低程度优于对照组(P<0.05);治疗后两组总胆固醇(TC)、三酰甘油(TG)水平高于治疗前,空腹血糖(FPG)水平、心率低于治疗前,且观察组改善程度好于对照组(P<0.05),治疗后观察组不良反应发生率低于对照组(P<0.05);观察组复发率与对照组比较,差异未见统计学意义(P>0.05)。结论甲巯咪唑联合普萘洛尔治疗甲亢,有效调控血糖、血脂水平,保护患者甲状腺、肝功能,且复发率较低,安全性高。
Objective To study the curative effect of methimazole combined with propranolol on hyperthyroidism and its influences on liver function.Methods A total of 95 hyperthyroidism patients in Pingdingshan Pingmei Shenma Medical Group General Hospital from May 2018 to May 2019 were enrolled as the research objects.They were randomly divided into control group(46 cases,methhimazole)and observation group(49 cases,methimazole combined with propranolol).The levels of thyroid hormones,liver function indexes and biochemical indexes before and after treatment were compared between the two groups.The clinical curative effect,adverse reactions and recurrence in both groups were evaluated.Results The clinical response rate of observation group was higher than that of control group(P<0.05).After treatment,levels of free triiodothyronine(FT3),free thyroxine(FT4)and thyrotropin receptor antibody(TRAb)in both groups were decreased,whose improvement was better in observation group than control group(P<0.05).After treatment,levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and serum total bilirubin(TBIL)in both groups were decreased,whose decrease amplitude was better in observation group than control group(P<0.05).After treatment,levels of total cholesterol(TC)and triglyceride(TG)were increased,while level of fasting plasma glucose(FPG)and heart rate were decreased in both groups,whose improvement was better in observation group than control group(P<0.05).After treatment,the incidence of adverse reactions in observation group was lower than that in control group(P<0.05).There was no significant difference in the recurrence rate between the observation group and the control group(P>0.05).Conclusions Methimazole combined with propranolol in the treatment of hyperthyroidism can effectively regulate levels of blood glucose and blood lipid,protect thyroid and liver function,with low recurrence rate and high safety.
作者
刘真真
朱慧琪
杜佳
Liu Zhenzhen;Zhu Huiqi;Du Jia(Second Ward of Endocrinology Department,Pingdingshan Pingmei Shenma Medical Group General Hospital,Pingdingshan 467000,China)
出处
《中国实用医刊》
2020年第24期97-100,共4页
Chinese Journal of Practical Medicine
