摘要
目的:探讨抗病毒滴丸治疗儿童流行性感冒的临床疗效。方法:将2019年12月至2020年2月天津中医药大学第一附属医院、秦皇岛市第二医院和丹东市第一医院收治的36例流行性感冒患儿随机分为研究组和对照组。研究组18例患儿口服抗病毒滴丸,对照组18例患儿口服磷酸奥司他韦颗粒,治疗5 d,停药观察2 d。观察两组患儿的临床痊愈情况、完全退热时间、加拿大急性呼吸道疾病和流行性感冒量表(Canadian acute respiratory illness and flu scale,CARIFS)症状维度评分、体温及不良反应发生情况,并将两组患儿的数据进行对比分析。结果:研究组患儿临床痊愈率为61.11%(11/18),终点痊愈时间为4 d;对照组患儿临床痊愈率为77.78%(14/18),终点痊愈时间为3 d;对照组患儿略优于研究组,但组间比较,差异无统计学意义(P>0.05)。在疾病完全退热时间、CARIFS症状维度评分及体温上,两组患儿比较,差异均无统计学意义(P>0.05)。本研究并未发现不良事件及不良反应。结论:抗病毒滴丸可有效抑制病毒,治疗儿童流行性感冒的效果明显,安全性高。
OBJECTIVE:To probe into the clinical efficacy of antiviral dropping pills in the treatment of influenza in children.METHODS:A total of 36 children with influenza admitted into the First Affiliated Hospital of Tianjin University of Chinese Medicine,the Second Hospital of Qinhuangdao City and the First Hospital of Dandong from Dec.2019 to Feb.2020 were randomly divided into the study group and the control group,with 18 cases in each group.The study group was given oral antiviral dropping pills,and the control group was given oral oseltamivir phosphate granules,with 5 d of treatment,2 d of drug withdrawal observation.Clinical recovery,duration of fever,symptom dimension score of the Canadian Acute Respiratory Illness and Flu Scale(CARIFS),body temperature and incidence of adverse drug reactions in two groups were observed,and the data of two groups were compared and analyzed.RESULTS:The clinical recovery rate in the study group was 61.11%(11/18),and the end point of recovery time was 4 d;the clinical recovery rate in the control group was 77.78%(14/18),and the recovery time was 3 d,the control group was slightly better than the study group,yet there was no significant difference between two groups(P>0.05).There was no statistically significant difference between two groups in terms of duration of fever,symptom dimension score of CARIFS and body temperature(P>0.05).No adverse drug events or adverse drug reactions were found in this study.CONCLUSIONS:The efficacy of antiviral dropping pills in the treatment of children with influenza is significant with higher safety,which can can effectively inhibit the virus.
作者
王真
王天亮
杨欢
WANG Zhen;WANG Tianliang;YANG Huan(Dept.of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Zhejiang Chinese Medical University,Zhejiang Hangzhou 310006,China;College of Chemistry and Life Sciences,Zhejiang Normal University,Zhejiang Jinhua 321000,China;First Clinical Medical College,Zhejiang Chinese Medical University,Zhejiang Hangzhou 310053,China)
出处
《中国医院用药评价与分析》
2021年第1期63-65,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
儿童
流行性感冒
抗病毒滴丸
临床疗效
Children
Influenza
Antiviral dropping pills
Clinical efficacy
