摘要
目的探讨原发性皮肤黏液癌(PCMC)的临床病理特点及临床预后,并复习相关文献。方法收集四川自贡市第四人民医院2012—2019年原发性皮肤黏液癌2例,对其临床资料、病理形态、免疫组织化学标记进行综合分析,总结相关临床病理资料及鉴别诊断,并复习相关文献。结果 2例原发皮肤黏液癌组织肉眼观察,肿瘤边界相对清楚,似有包膜,切面灰白,实性,部分区域半透明,质中,附有少许黏液。镜下观察,肿瘤组织均位于真皮浅层,累及皮下纤维组织,并可见大量黏蛋白湖形成,癌细胞呈岛状团块漂浮在淡染的黏蛋白湖中,黏液湖被纤维分隔成许多区域。免疫组化:CK7、ER、PR、和催乳素诱导蛋白-15(GCDFP-15)均呈(+),CK20、CDX-2、CA125、TTF-1、C-erbB-2、PSA和villin均(-),Ki-67低表达(<3%)。结论原发于皮肤的黏液癌是起源于汗腺的一种恶性肿瘤,好发于头面部,老年男性多见,病理组织学上与转移性黏液癌鉴别困难,需结合临床影像学及免疫组织化学标记排除转移癌后才可诊断。该肿瘤属于低度恶性肿瘤,治疗方案主要采用手术局部扩大切除,预后较好。
Objective To investigate the clinicopathological features and prognosis of primary cutaneous mucinous carcinoma(PCMC)with review of the related literature.Methods Two cases of primary cutaneous mucinous cancer from 2012 to 2019 were collected from the Fourth People’s Hospital of Zigong,Sichuan Province.The clinical data,pathological morphology and immunohistochemical markers were analyzed comprehensively.The clinicopathological changes and differential diagnosis were summarized,and the relevant literature was reviewed.Results Two cases of primary mucinous carcinoma of skin were observed by naked eyes.The tumor boundary was relatively clear,like a capsule.The cutting surface was gray and solid,some areas were translucent,with mucoid substance.Microscopically,the tumor was located in the superficial dermis,involving the subcutaneous fibrous tissue,and a large number of mucinous lakes were seen.The cancer cells presented island like masses floating in the lightly stained mucinous lakes,which were divided into many areas by fibers.Cytokeratin(CK)7,estrogen receptor(ER),progesterone receptor(PR),and prolactin induced protein-15(GCDFP-15)were all positive.CK20,Cdx-2,CA125,TTF-1,C-erbB-2 and PSA were negative.There was no expression of villin and low expression of Ki-67(<3%).Conclusion Primary mucinous carcinoma of the skin is a malignant tumor originated from sweat glands,which is more common in the head and face.It is difficult to differentiate it from metastatic mucinous carcinoma in histopathology.It can only be diagnosed after the removal of metastatic carcinoma by combining clinical imaging and immunohistochemical markers.The tumor belongs to low-grade malignant tumor,and the treatment mainly adopts local extended resection with good prognosis.
作者
邹龙权
卢子剑
陈芊杏
刘官智
兰雪梅
王勇
程序
ZOU Long-quan;LU Zi-jian;CHEN Qian-xing;LIU Guan-zhi;LAN Xue-mei;WANG Yong;CHENG Xu(Department of Pathology,Fourth People's Hospital,Zigong 643000,China;Department of Dermatology,the Fourth People's Hospital,Zigong 643000,China)
出处
《诊断病理学杂志》
2021年第1期42-46,共5页
Chinese Journal of Diagnostic Pathology
关键词
癌症
皮肤肿瘤
病理学
免疫组化
Cancer
Skin tumor
Pathology
Immunohistochemistry
