摘要
目的:探讨壮药食疗复方红根粳米粥防治小儿反复呼吸道感染的临床疗效。方法:将80例反复呼吸道感染患儿随机分为治疗组和对照组,每组各40例。对照组给予口服细菌溶解产物胶囊治疗,治疗组在对照组基础上加服壮药食疗复方红根粳米粥。观察2组在治疗后3、6、12个月的综合疗效、中医证候积分、血清免疫球蛋白(IgA、IgG、IgM)水平、T细胞亚群指标(CD3、CD4、CD8)的变化。结果:治疗过程中治疗组和对照组各脱落2例。治疗后12个月综合疗效总有效率治疗组为97.4%(37/38),优于对照组的84.2%(32/38),差异有统计学意义(P<0.05)。2组中医证候积分治疗后3、6、12个月均有不同程度的下降,且治疗组治疗6、12个月后的下降程度较对照组更为明显,组内及组间差异均有统计学意义(P<0.05)。治疗后6、12个月IgG值,3、6、12个月IgM值,12个月IgA值与本组治疗前比较,及治疗后6、12个月IgG、IgM值,治疗后12个月IgA值与对照组同期比较,差异均有统计学意义(均P<0.05)。2组CD4、CD8治疗后12个月与治疗前比较以及与对照组同期比较,差异均有统计学意义(均P<0.05)。结论:长期服用壮药食疗复方红根粳米粥可提高小儿反复呼吸道感染的免疫功能,对机体免疫球蛋白和T细胞亚群具有调节作用。
Objective:To investigate the clinical effect of the compound Zhuang medicine dietary prescription Honggen Jingmi porridge in the prevention and treatment of recurrent respiratory infection in children.Methods:A total of 80 children with recurrent respiratory infection were randomly divided into treatment group and control group,with 40 patients in each group.The patients in the control group were given oral bacterial lysate capsules,and those in the treatment group were given the compound Zhuang medicine dietary prescription Honggen Jingmi porridge in addition to the treatment in the control group.Both groups were observed in terms of overall response and changes in traditional Chinese medicine(TCM)syndrome score,serum levels of immunoglobulins(IgA,IgG,and IgM),and T lymphocyte subsets(CD3,CD4,and CD8)at 3,6,and 12 months after treatment.Results:Two patients in the treatment group and two in the control group were lost to follow-up.At 12 months after treatment,the treatment group had a significantly higher overall response rate than the control group[97.4%(37/38)vs 84.2%(32/38),P<0.05].Both groups had varying degrees of reduction in TCM syndrome score at 3,6,and 12 months after treatment,and the treatment group had a significantly greater reduction than the control group at 6 and 12 months after treatment(all P<0.05).Both groups showed significant changes in IgG(at 6 and 12 months after treatment),IgM(at 3,6,and 12 months after treatment),and IgA(at 12 months after treatment),and there were significant differences between the two groups in IgG and IgM at 6 and 12 months after treatment and IgA at 12 months after treatment(all P<0.05).Both groups had significant changes in CD4 and CD8 at 12 months after treatment,and there were significant differences in CD4 and CD8 between the two groups at 12 months after treatment(all P<0.05).Conclusion:In children with recurrent respiratory infection,long-term administration of the compound Zhuang medicine dietary prescription Honggen Jingmi porridge can improve immune function and regulate immunoglobulins and T lymphocyte subsets.
作者
韦杏
邹敏
农志飞
李崇进
冯智琼
杨振亚
李景魏
WEI Xing;ZOU Min;NONG Zhifei;LI Chongjin;FENG Zhiqiong;YANG Zhenya;LI Jingwei(Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China;Guangxi International Zhuang Medicine Hospital,Nanning 530001,Guangxi,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China;Bose Hospital of Traditional Chinese Medicine,Bose 533000,Guangxi,China)
出处
《湖南中医杂志》
2021年第1期9-12,共4页
Hunan Journal of Traditional Chinese Medicine
基金
广西壮族自治区高校壮医方药基础与应用研究重点实验室科研项目(zyfy201605)
广西中医药大学校级重点项目(2017D002)
广西高校中青年教师基础能力提升项目(2018KY0302)。
关键词
儿童反复呼吸道感染
壮药食疗复方
红根粳米粥
pediatric recurrent respiratory infection
compound Zhuang medicine dietary prescription
Honggen Jingmi porridge
