摘要
目的了解孟鲁司特钠致不良反应(ADR)发生的特点和规律,为临床安全用药提供参考。方法检索中国期刊网全文数据库、维普中文科技期刊数据库、万方数据库2000年1月~2019年12月国内公开报道的孟鲁司特钠ADR的个案文献报道,进行分析。结果筛选到29篇,32例ADR,其中男22例(68.75%),女10例(31.25%),年龄12个月~86岁,且多发生于用药后1~3 d(34.38%)。原患疾病多为支气管哮喘、支气管炎;ADR累及系统/器官主要为神经及精神系统、皮肤及其附件和泌尿系统。结论应加强对孟鲁司特钠ADR的监测,以保证安全合理用药。
Objective To investigate the characteristics and regularity of adverse drug reactions(ADR)induced by Montelukast Sodium and provide reference for safe drug use in clinic.Methods The papers of CNKI,VIP and Wangfang were retrieved and analyzed for collecting ADR reports induced by Montelukast Sodium from January 2000 to December 2019.Results This study screened 29 articles with 32 cases of ADR.In the 32 cases of ADR,22 cases(68.75%)were male and 10 cases(31.25%)were female,the youngest patient was 12 months,the oldest patient was 86 years old,and mainly occurred 1 to 3 d after medication(34.38%).Patients mainly suffered from bronchial asthma,bronchitis.Systems/organs involved in ADR were the nervous and mental system,skin and its accessories,and urinary system.Conclusion The ADR monitoring should be strengthened for ensuring safe and rational use of Montelukast Sodium.
作者
周梁
赵江燕
董美美
黄文跃
唐存阳
ZHOU Liang;ZHAO Jiang-yan;DONG Mei-mei;HUANG Wen-yue;TANG Cun-yang(Departmen of Pharmacy,Women-Children's Hospital of Guilin,Guangxi Zhuang Autonomous Region,Guilin 541001,China)
出处
《中国当代医药》
CAS
2021年第4期200-202,共3页
China Modern Medicine
关键词
孟鲁司特钠
不良反应
文献分析
中国
Montelukast Sodium
Adverse drug reactions
Literature analysis
China
