摘要
目的探讨生长抑素治疗食管胃静脉曲张出血(EGVB)患者的效果及护理。方法选取2020年4~7月沈阳市第六人民医院收治的80例EGVB患者,按照随机数字表法分为对照组和试验组,每组各40例。对照组采用特利加压素治疗,试验组在对照组的基础上联合生长抑素治疗,两组均治疗期给予综合护理干预,治疗周期为3 d,护理干预至出院。比较两组治疗的止血时间、输血量及治疗后再出血率,T0~T4时段中心静脉压(CVP)、门脉静压(PVP)和血清胃动素(MTL)、胃泌素(GAS)、胰高血糖素(GLC)水平。结果治疗中试验组的止血时间短于对照组,差异有统计学意义(P<0.05),两组的输血量比较,差异无统计学意义(P>0.05),治疗后两组的再出血率比较,差异无统计学意义(P>0.05);与治疗前比较,治疗后两组的CVP值无明显变化,而PVP与血清MTL、GAS、GLC水平均降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。结论生长抑素可显著改善EGVB患者血液动力学水平和血清GAS、MTL、GLC水平,提升治疗的效果。
Objective To investigate the effect of Somatostatin in the treatment of patients with esophageal-gastric varices bleeding(EGVB) and nursing care. Methods A total of 80 EGVB patients admitted to Shenyang Sixth People′s Hospital from April to July 2020 were selected and divided into the control group(n=40) and the treatment group(n=40) according to the random number table method. The control group was treated with conventional Terley Vasopressin,while the treatment group treate with Somatostatin on the basis of the control group. The two groups were treated with comprehensive nursing intervention and treatment until discharge from hospital, and the treatment cycle was 3 d. The hemostasis time, blood transfusion volume in the process of treatment and rebleeding rate after treatment were compared between two groups;the changes of central venous pressure(CVP), portal static pressure(PVP) and motilin(MTL), gastrin(GAS), glucagon(GLC) in the serum in T0-T4 period were compared between the two groups. Results The hemostasis time of the treatment group was shorter than that of the control group, the difference was statistically significant(P<0.05). There was no significant difference in blood transfusion volume between the two groups(P>0.05),there was no significant difference in rebleeding rate between the two groups after treatment(P>0.05). Compared with before treatment, there was no significant change of CVP in the two groups after treatment(P>0.05). The levels of PVP,MTL, GAS and GLC in the serum of the two groups all decreased after treatment, and the indexes in the treatment group were lower than those of the control group, the differences were statistically significant(P<0.05). Conclusion Somatostatin can significantly improve the hemodynamic indexes and gastrointestinal hormone GAS, MTL, GLC in the serum in EGVB patients, and enhance the therapeutic effect.
作者
高焱
GAO Yan(The First of Department of Gastroenterology,Shenyang Sixth People's Hospital,Liaoning Province,Shenyang 110001,China)
出处
《中国当代医药》
CAS
2021年第6期226-229,共4页
China Modern Medicine
