摘要
目的:采用网状Meta分析综合比较10种口服中成药联合化疗治疗胃癌的疗效和安全性。方法:计算机检索PubMed,Embase,Web of Science,Cochrane Library,中国知网、中国生物医学文献服务系统、维普网、万方数据库,检索时间为建库至2020年3月1日。对纳入的随机对照试验(RCT)进行筛选、提取数据和便宜风险评价。然后采用RevMan 5.3软件进行Meta分析,ADDIS 1.16.7进行网状Meta分析。结果:共纳入41项随机对照研究,均为双臂,包含10种口服中成药,分析结果显示,与单纯化疗相比,华蟾素,金龙胶囊,平消胶囊,参一胶囊,消癌平片,西黄丸(或胶囊),养正消积胶囊,贞芪扶正颗粒联合化疗治疗胃癌的有效率明显提高(P<0.05),贞芪扶正+化疗方案排序最高;华蟾素、参一胶囊、养正消积胶囊、贞芪扶正颗粒联合化疗治疗胃癌的KPS改善率明显提高(P<0.05),参一胶囊+化疗方案为最优;金龙胶囊、养正消积联合化疗能明显降低恶心呕吐的发生率(P<0.05),华蟾素联合化疗治疗胃癌的白细胞下降发生率明显降低(P<0.05),贞芪扶正颗粒为最佳;各中成药均不能降低神经毒性发病率;华蟾素、养正消积胶囊、贞芪扶正颗粒联合化疗治疗可提升胃癌患者血液中CD4+/CD8+(P<0.05)。结论:口服中成药联合化疗治疗胃癌在各方面发挥优势,贞芪扶正颗粒、养正消积胶囊、参一胶囊对生存改善、降低不良反应有较好的疗效。
Objective:To compare the efficacy and safety of 10 kinds of oral Chinese patent medicines combined with chemotherapy in the treatment of gastric cancer in a network Meta-analysis. Method: PubMed,Embase,Web of Science,Cochrane Library,CNKI,China biomedical literature service system,VIP,Wanfang database were retrieved to obtain Chinese and English literatures published before March 1,2020. The randomized controlled trials(RCTs)and data were screened and extracted. The quality of the included literatures was also evaluated. The pair-work Meta-analysis was conducted by Revman 5.3 software,and the Meta-analysis were conducted by ADDIS 1.16.7 software. Result: A total of 41 randomized controlled trials were eventually involved. All of them were two-arm,including 10 oral Chinese patent medicines,Cinobufotalin,Jinlong capsule,Pingxiao capsule,Shenyi capsule,Xihuang pill(or capsule),Xiaoaiping tablet,Yangzheng Xiaoji capsule,Zhenqi Fuzheng granule combined with chemotherapy for gastric cancer. The effective rate for treating cancer was significantly higher than that of chemotherapy alone(P<0.05). Zhenqi Fuzheng+chemotherapy was the best choice;the KPS improvement rate of Cinobufacin,Shenyi capsule,Yangzheng Xiaoji capsule,Zhenqi Fuzheng granule combined with chemotherapy in the treatment of gastric cancer was significantly increased(P<0.05).Shenyi capsule combined with chemotherapy might be the best regimen. The incidence rate of leukocyte decline was significantly lower in the treatment of gastric cancer(P<0.05). The combination of Zhenqi Fuzheng granule and chemotherapy was the best choice. Traditional Chinese medicine could not reduce the incidence of neurotoxicity(P>0.05). Cinobufufacin,Yangzheng Xiaoji capsule and Zhenqi Fuzheng granule combined with chemotherapy could increase CD4~+/CD8~+ in patients with gastric cancer,which was significantly higher than that of chemotherapy alone(P<0.05). Conclusion: All kinds of oral Chinese patent medicines can play a significantly role in the treatment of gastric cancer. Zhenqi Fuzheng granule,angzheng Xiaoji capsule and Shenyi capsule combined with chemotherapy are more effective in treating gastric cancer.
作者
杨杰
罗秀丽
朱露
刘嘉敏
徐忆芳
YANG Jie;LUO Xiu-li;ZHU Lu;LIU Jia-min;XU Yi-fang(Hubei University of Chinese Medicine,Wuhan 430061,China;Hubei Hospital of Traditional Chinese Medical,Wuhan 430061,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第2期181-195,共15页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家中医药管理局中医药循证能力建设项目(2019XZZX-ZL002)。
关键词
10种口服中成药
联合化疗
胃癌
网状Meta分析
有效性
安全性
10 kinds of oral Chinese patent medicines
combined chemotherapy
gastric cancer
reticular Meta-analysis
effectiveness
safety
