摘要
目的分析左旋氨氯地平联合依那普利治疗尿毒症肾性高血压的临床效果。方法80例尿毒症肾性高血压患者,根据治疗方法不同分为对照组和联合治疗组,每组40例。对照组给予左旋氨氯地平治疗,联合治疗组给予左旋氨氯地平联合依那普利治疗。比较两组生存质量评分,治疗前后肾功能指标、收缩压和舒张压水平,临床疗效。结果联合治疗组患者的生存质量评分(92.21±3.45)分高于对照组的(75.26±3.12)分,差异具有统计学意义(P<0.05)。治疗后,两组24 h蛋白尿、血肌酐、尿素氮、收缩压和舒张压水平均较治疗前降低,且联合治疗组24 h蛋白尿、血肌酐、尿素氮、收缩压和舒张压水平均显著低于对照组,差异具有统计学意义(P<0.05)。联合治疗组患者的治疗总有效率95.00%显著高于对照组的75.00%,差异具有统计学意义(P<0.05)。结论左旋氨氯地平联合依那普利治疗尿毒症肾性高血压的疗效确切,可一定程度改善生存质量和肾功能,降低患者收缩压和舒张压,提高治疗效果,值得推广。
Objective To analyze the clinical effect of levamlodipine combined with enalapril in the treatment of uremic renal hypertension.Methods A total of 80 patients with uremic renal hypertension were divided into control group and combined treatment group according to different treatment methods,with 40 cases in each group.The control group was treated with levamlodipine,and the combined treatment group was treated with levamlodipine combined with enalapril.The quality of life score,renal function indexes,systolic blood pressure and diastolic blood pressure levels before and after treatment,and clinical efficacy were compared between the two groups.Results The quality of life score(92.21±3.45)points of combined treatment group was higher than(75.26±3.12)points of the control group,and the difference was statistically significant(P<0.05).After treatment,the 24 h proteinuria,blood creatinine,urea nitrogen,systolic blood pressure and diastolic blood pressure of the two groups were lower than those before treatment,and the combined treatment group was significantly lower than the control group.The difference was statistically significant(P<0.05).The total effective rate of treatment 95.00%of combined treatment group was significantly higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion Levamlodipine combined with enalapril shows affirmative effect in the treatment of uremic renal hypertension,which can improve the quality of life and renal function,reduce systolic blood pressure and diastolic blood pressure,and improve the therapeutic effect,which is worth popularizing.
作者
贾云凤
JIA Yun-feng(Department of Nephrology,Zhuanghe Traditional Chinese Medicine Hospital,Zhuanghe 116400,China)
出处
《中国实用医药》
2021年第6期89-92,共4页
China Practical Medicine
