摘要
目的分析早产儿缺血缺氧性脑病(HIE)的CT、MR影像表现及其与D-D、ApoA水平的相关性。方法选取2011年6月—2020年3月河北省邯郸市中心医院新生儿科诊治HIE早产儿57例为病例组,以同期同胎龄、同出生体质量的颅脑正常早产儿43例作为对照组,2组均完善CT、MR影像学检查及血液D-D、ApoA检测,分析CT、MR影像学特征并以其对HIE进行分度(轻度、中度、重度),比较2组不同临床分度与CT、MR分度患儿的血液D-D、ApoA水平。进而分析CT分度、MR分度与D-D、ApoA的相关性。结果HIE患儿CT、MR主要表现为脑室周围白质密度降低/信号异常,可合并脑叶低密度灶/信号异常、脑室出血、蛛网膜下腔出血、室管膜下出血、脑梗死、脑室周围白质软化等征象。病例组不同临床HIE分度、CT分度、MR分度与对照组D-D比较差异均有统计学意义(F/P=36.548/0.000、26.947/0.000、29.665/0.000),HIE患儿血中D-D含量高于对照组,且随HIE分度严重程度而增加,但差异无统计学意义(P>0.05)。病例组不同临床HIE分度、CT分度、MR分度与对照组ApoA比较差异均有统计学意义(F/P=52.964/0.000、44.285/0.000、38.026/0.000),HIE患儿血中ApoA水平高于对照组,且随HIE分度严重程度而增加,但差异无统计学意义(P>0.05)。CT分度、MR分度与D-D、ApoA呈正相关。结论早产儿HIE的CT、MR分度与临床分度诊断效能基本一致,均可较好地诊断HIE,且CT、MR分度与D-D、ApoA呈正相关。
Objective Analyze the CT and MR imaging manifestations of hypoxic ischemic encephalopathy(HIE)in premature infants and their correlation with D dimer and Apoa levels.Methods From June 2011 to March 2020,57 cases of HIE preterm infants diagnosed and treated in the Department of Neonatology,Handan Central Hospital,Hebei Province were selected as the case group,and 43 cases of normal cranial preterm infants with the same gestational age and birth weight were selected as the control group.Both groups have perfected CT and MR imaging examinations and blood D dimer and Apoa tests,analyzed CT and MR imaging characteristics and used them to grade HIE(mild,moderate,severe),and compared the two groups with different clinical grades.The blood D dimer and Apoa levels in CT and MR scales.Then analyze the correlation between CT scale,MR scale and D dimer,Apoa.Results CT and MR in children with HIE mainly manifested as decreased periventricular white matter density/abnormal signal,which may be associated with low-density lobe/abnormal signal,intraventricular hemorrhage,subarachnoid hemorrhage,subependymal hemorrhage,cerebral infarction,periventricular white matter Softening and other signs.There were statistically significant differences between the clinical HIE scale,CT scale,MR scale of the case group and the control group D dimer(F/P=36.548/0.000,26.947/0.000,29.665/0.000).The blood D dimer of children with HIE The content was higher than that of the control group,and it increased with the severity of HIE scale,but the difference was not statistically significant(P>0.05).There were statistically significant differences between the different clinical HIE scales,CT scales,MR scales of the case group and the control group Apoa(F/P=52.964/0.000,44.285/0.000,38.026/0.000).The level of Apoa in the blood of children with HIE was higher than that in the control group,and it increased with the severity of HIE scale,but the difference was not statistically significant(P>0.05).CT scale and MR scale are positively correlated with D dimer and Apoa.Conclusion The diagnostic efficiency of CT and MR grading of HIE in premature infants is basically the same as that of clinical grading,and HIE can be diagnosed well,and CT and MR grading are positively correlated with D dimer and Apoa.
作者
翟丽娜
闫丽娟
张晓丽
平莉莉
翟淑芬
Zhai Lina;Yan Lijuan;Zhang Xiaoli;Ping Lili;Zhai Shufen(Department of Neonatology, Handan Central Hospital, Hebei Province, Handan 056000,China)
出处
《疑难病杂志》
CAS
2021年第2期139-143,147,共6页
Chinese Journal of Difficult and Complicated Cases
基金
河北省重点研发计划自筹项目(182777236)。
关键词
缺血缺氧性脑病
早产儿
影像学检查
D-二聚体
脂蛋白A
相关性
Hypoxic ischemic encephalopathy
Premature infant
Imaging examination
D dimer
Lipoprotein a
Correlation
