摘要
目的:探讨结直肠癌组织中肌动蛋白凝胶蛋白(transgelin,TAGLN)及肌动蛋白凝胶蛋白2(transgelin2,TAGLN2)的表达及其临床意义。方法:选取2012年至2013年在郑州大学附属肿瘤医院接受结直肠癌根治术治疗的89例结直肠癌患者病理组织标本及配对癌旁组织,采用免疫组织化学检测TAGLN和TAGLN2在结直肠癌组织中的表达情况,结合临床资料分析TAGLN、TAGLN2与结直肠癌患者临床病理特征及预后的关系。结果:TAGLN在结直肠癌组织中的阳性表达率为60.7%(54/89),明显高于癌旁组织38.2%(34/89),差异有统计学意义(P<0.05),TAGLN表达与结直肠癌患者的TNM分期、肿瘤分化程度、Ki67表达、淋巴结转移及远处转移明显相关(P均<0.05);TAGLN2在结直肠癌组织中的阳性表达率为69.7%(62/89),明显高于癌旁组织31.5%(28/89),差异有统计学意义(P<0.01),TAGLN2表达与结直肠癌患者的肿瘤分化程度、Ki67表达及远处转移显著相关(P均<0.05)。相关分析显示, TAGLN蛋白表达与TAGLN2蛋白表达呈正相关(r=0.219,P=0.039)。Kaplan-Meier生存分析显示,患者生存时间与肿瘤分化程度、TNM分期、Ki67表达、远处转移、TAGLN和TAGLN2有关,差异有统计学意义(P均<0.05);多因素Cox回归结果显示,远处转移、TNM分期和TAGLN是影响结直肠癌患者预后的独立危险因素(P均<0.05)。结论:对于结直肠癌患者,TAGLN的表达与TNM分期、肿瘤分化程度、Ki67表达、淋巴结转移和远处转移有关,TAGLN2的表达与肿瘤分化程度、Ki67表达和远处转移有关。TAGLN表达、TNM分期和远处转移为结直肠癌患者预后的独立影响因素。
Objective:To investigate the relationship of transgelin(TAGLN) and transgelin 2(TAGLN2) expression in colorectal carcinoma tissues and the clinical pathological characteristics and prognosis of the patients.Methods:Eighty-nine cases of colorectal cancer surgical resection samples were collected from 2012 to 2013 in Affiliated Tumor Hospital of Zhengzhou University.The expression of TAGLN and TAGLN2 was assessed by immunohistochemistry.The relationship between TAGLN,TAGLN2 and clinicopathological features and prognosis of CRC patients combinedthe clinical data.Results:The positive expression rate of TAGLN in colorectal cancer tissues was 60. 7%(54/89),which was significantly higher than 38. 2%(34/89) in adjacent tissues,with statistically significant differences(P<0. 05),and the expression of TAGLN was related to TNM staging,tumor differentiation,Ki67,lymph node metastasisand distant metastasis(allP< 0. 05). The positive expression rate of TAGLN2 in colorectal cancer tissues was 69. 7%(62/89),significantly higher than that in adjacent tissues 31. 5%(28/89),and the difference was statistically signif-icant(P< 0. 01),and the expression of TAGLN2 was significantly correlated with the degree of tumor differentiation,Ki67 and distant metastasis in colorectal cancer patients(allP< 0. 05). The correlation analysis showed that the ex-pressions of TAGLN was positively correlated with TAGLN2(r= 0. 219,P= 0. 039). Kaplan-meier survival analysisshowed that the survival time was related to tumor differentiation,TNM stage,Ki67,distant metastasis and the expres-sion of TAGLN and TAGLN2(allP< 0. 05). Cox multivariate analysis showed that TNM stage,distant metastasis,TAGLN were independent factors influencing the prognosis of colorectal cancer patients(allP< 0. 05).Conclusion:To CRC patients,the expression of TAGLN is associated with TNM stage,tumor differentiation,Ki67,lymph node me-tastasis and distant metastasis while TAGLN2 is associated with tumor differentiation,Ki67 and distant metastasis.TNM stage,distant metastasis and TAGLN were independent prognostic factors in CRC patients.
作者
陈瑜
崔发财
宋魏
王佳琪
夏庆欣
CHEN Yu;CUI Facai;SONG Wei;WANG Jiaqi;XIA Qingxin(Department of Pathology,Affiliated Tumor Hospital of Zhengzhou University,Henan Zhengzhou 450008,China;Clinical Laboratory,Henan Province People's Hospital,Henan Zhengzhou 450003,China)
出处
《现代肿瘤医学》
CAS
北大核心
2021年第5期823-828,共6页
Journal of Modern Oncology
基金
河南省医学科技攻关计划项目(编号:201702246)。
