摘要
线粒体是心肌能量代谢的主要场所,其通过分裂和融合的动态平衡维持正常的形态和功能。线粒体分裂和融合的动态转换称为线粒体动力学,受线粒体融合和分裂相关蛋白等多种蛋白调控。线粒体动力失衡可引起心脏结构和功能的紊乱,参与扩张型心肌病、缺血再灌注损伤、脓毒性心肌病、糖尿病心肌病和动脉粥样硬化等心血管疾病的发生和发展。维持线粒体动力平衡可作为治疗这些疾病的新靶点。现综述线粒体分裂和融合的机制及其失衡对相关心血管疾病的影响。
Mitochondria is the main site of energy metabolism in myocardium,which maintains normal morphology and function through the dynamic balance of division and fusion.The dynamic transformation of mitochondrial division and fusion is called mitochondrial dynamics,which is regulated by mitochondrial fusion-related proteins,division-related proteins and other proteins.The imbalance of mitochondrial dynamics can cause disorders of cardiac structure and function,and participate in the occurrence and development of cardiovascular diseases such as dilated cardiomyopathy,ischemia-reperfusion injury,septic-induced cardiomyopathy,diabetic cardiomyopathy and atherosclerosis.Maintaining mitochondrial dynamic balance can be a new target for the treatment of these diseases.This article reviews the mechanism of mitochondrial divison and fusion and the influence of imbalance on related cardiovascular diseases.
作者
宋元秀
崔鸣
SONG Yuanxiu;CUI Ming(Department of Cardiology,Peking University Third Hospital,Beijing 100191,China)
出处
《心血管病学进展》
CAS
2021年第2期162-166,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金面上项目(82070272)。
关键词
线粒体动力学
扩张型心肌病
缺血再灌注损伤
脓毒性心肌病
糖尿病心肌病
动脉粥样硬化
Mitochondrial dynamics
Dilated cardiomyopathy
Ischemia-reperfusion injury
Septic-induced cardiomyopathy
Diabetic cardiomyopathy
Atherosclerosis
