摘要
目的探讨非小细胞肺癌活检标本中细胞角蛋白(CK)5/6、P40的表达水平及临床价值。方法选取2017年1月至2019年12月我院收治的120例非小细胞肺癌患者作为研究对象,采集患者肺部病灶组织作为活检标本,采用免疫组织化学SP法测定CK5/6、P40表达水平。比较不同病理分型活检标本的CK5/6、P40表达情况,并分析CK5/6、P40检测对肺鳞癌的诊断结果及诊断效能。结果CK5/6、P40在肺鳞癌标本中的阳性表达率均高于肺腺癌标本(P<0.05)。CK5/6检测、P40检测对肺鳞癌的诊断灵敏度、阳性预测值、阴性预测值比较,差异无统计学意义(P>0.05);而CK5/6检测的特异度、准确度均高于P40检测(P<0.05)。结论CK5/6、P40主要表达于肺鳞癌标本中,CK5/6、P40检测可对肺鳞癌与肺腺癌进行准确鉴别,CK5/6、P40可作为非小细胞肺癌病理分型鉴别诊断的重要辅助指标。
Objective To explore the expression levels and clinical value of cytokeratin(CK)5/6 and P40 in biopsy specimens of non-small cell lung cancer.Methods A total of 120 patients with non-small cell lung cancer admitted in our hospital from January 2017 to December 2019 were selected as the research objects.The lung lesions tissue were collected as biopsy specimens.The expression levels of CK5/6 and P40 were determined by immunohistochemistry SP method.The expression of CK5/6 and P40 in biopsy specimens of different pathological types were compared,and the diagnostic results and diagnostic efficacy of CK5/6 and P40 detection for lung squamous cell carcinoma were analyzed.Results The positive expression rates of CK5/6 and P40 in lung squamous cell carcinoma specimen were higher than those in lung adenocarcinoma specimen(P<0.05).There were no significant differences in the sensitivity,positive predictive value and negative predictive value of CK5/6 detection and P40 detection in the diagnosis of lung squamous cell carcinoma(P>0.05),while the specificity and accuracy of CK5/6 detection were higher than those of P40 detection(P<0.05).Conclusion CK5/6 and P40 are mainly expressed in lung squamous cell carcinoma.The detection of CK5/6 and P40 can accurately differentiate lung squamous cell carcinoma from lung adenocarcinoma.CK5/6 and P40 can be used as important auxiliary indexes in the differential diagnosis of pathological types of non-small cell lung cancer.
作者
路敏
LU Min(Beijing Renhe Hospital,Beijing 102600,China)
出处
《临床医学研究与实践》
2021年第6期32-33,42,共3页
Clinical Research and Practice
关键词
非小细胞肺癌
细胞角蛋白5/6
P40
肺鳞癌
肺腺癌
non-small cell lung cancer
cytokeratin 5/6
P40
lung squamous cell carcinoma
lung adenocarcinoma
