摘要
Hedgehog信号通路是人类胚胎发育的关键途径,异常激活与多种恶性肿瘤的发生和侵袭有必然的联系。随着肿瘤靶向药物的研究,针对Hedgehog信号通路的新靶标开发已成为抗癌治疗中越来越受关注的课题。临床研究证实,Hedgehog信号通路抑制剂对抗恶性肿瘤异质性取得了阶段性的进展。本文就靶向Hedgehog信号通路与肿瘤关系研究进展进行综述。
Hedgehog signaling pathway is the key approaches to human embryonic development,abnormal activation is associated with the occurrence and invasion of various malignant tumors.With the development of tumor targeting drugs,the development of new targets for Hedgehog pathway has become a more and more important topic in anti-cancer therapy.Clinical studies have confirmed that Hedgehog pathway inhibitors have achieved phased gains in the fight against the heterogeneity of malignant tumors.In this paper,we review the research progress of the relationship between Hedgehog signaling pathway and tumor.
作者
罗刚
祖旭宇
尹丽阳
申莹莹
Luo Gang;Zu Xuyu;Yin Liyang;Shen Yingying(Institute of Clinical Medicine,the First Affiliated Hospital of Nanhua University,Hunan Hengyang 421001)
出处
《中国社区医师》
2021年第7期6-7,共2页
Chinese Community Doctors
基金
国家自然科学基金(81972487)
湖南省自然科学基金(2019JJ50552,2020JJ4551)
湖南省卫健委一般项目(20201926)
湖南省教育厅重点项目(18A255)。
