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77例注射用复方三维B(Ⅱ)药品不良反应临床病例及文献分析 被引量:2

Clinical cases and literature analysis of 77 cases of adverse drug reactions induced by compound trivitamin B(Ⅱ)for injection
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摘要 目的:分析注射用复方三维B(Ⅱ)药品不良反应(ADR)发生的特点和规律,促进临床合理用药。方法:收集我院2016年1月-2020年12月使用注射用复方三维B(Ⅱ)发生ADR的病例信息,同时检索CNKI、万方、维普及PubMed数据库中注射用复方三维B(Ⅱ)致ADR的病例报道,统计分析ADR相关信息。结果:共计纳入ADR病例77例,我院临床病例45例,文献报道病例32例。65例(84.42%)ADR发生于用药后30min内,临床表现以全身性损害、皮肤及其附件损害和循环系统损害、呼吸系统损害最多。结论:临床医师应掌握注射用复方三维B(Ⅱ)的ADR发生特点,用药过程中需严密监测,减少ADR对患者造成的损害。 Objective:To analyze the general information and clinical characteristics of adverse drug reactions(ADR)induced by compound trivitamin B(Ⅱ)for injection in order to promote rational drug use.Methods:Cases with ADR induced by compound trivitamin B(Ⅱ)for injection in our hospital from January 2016 to December 2020 were collected.And case reports of ADR induced by compound trivitamin B(Ⅱ)for injection were retrieved from databases including CNKI,Wanfang,VIP and PubMed at the same time.Relevant information of them were summarized and analyzed.Results:A total of 77 cases were collected,among which 45 cases were from our hospital and 32 cases were from literature.The occurrent time of ADR of 65 cases(84.42%)were within 30 minutes after administration.Systematic injury and injury of skin and its attachment,circulatory system,respiratory system were the commonly clinical manifestations.Conclusion:Clinicians should be aware of the characteristics of ADR induced by compound trivitamin B(Ⅱ)for injection.It should be closely monitored during the course of using compound trivitamin B(Ⅱ)for injection in order to reduce the relevant injuries to patients.
作者 马志娜 于倩 关丽英 MA Zhi-na;YU Qian;GUAN Li-ying(Department of Pharmacy,China-Japan Union Hospital of Jilin University,Changchun 130033,China)
出处 《中国药物应用与监测》 CAS 2021年第1期31-34,共4页 Chinese Journal of Drug Application and Monitoring
基金 吉林省药品再评价协会项目[(2019)科技字(2306)号]。
关键词 注射用复方三维B(Ⅱ) 药品不良反应 安全性分析 Compound trivitamin B(Ⅱ)for injection Adverse drug reaction Safety analysis
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