摘要
目的探讨奥美拉唑治疗胃溃疡的有效性。方法观察对象为本院2018年全年医治的110名胃溃疡患者,经数字表法,把这些对象随机归入两组,对照组进行常规奥美拉唑治疗,研究组进行艾司奥美拉唑镁肠溶片治疗。比较两组患者疗效、钙素基因相关肽(CGRP)、白细胞介素-17(IL-17)、白细胞介素-10(IL-10)、高迁移率族蛋白B1(HMGB1)、幽门螺杆菌清除率。结果研究组疗效高于于对照组(P<0.05);研究组CGRP、IL-10水平高于对照组(P<0.05),研究组IL-17、HMGB1水平相较对照组偏低(P<0.05);在幽门螺杆菌清除率此项指标上,相较对照组,研究组偏高(P<0.05)。结论胃溃疡治疗中,艾司奥美拉唑镁肠溶片治疗效果显著,值得应用。
Objective To investigate the effectiveness of omeprazole in the treatment of gastric ulcer.Methods The observation subjects were 110 patients with gastric ulcer treated in our hospital in the whole year of 2018.These subjects were randomly divided into two groups by the number table method.The control group was treated with conventional omeprazole.The study group was treated with Aime Ogilvy.Lazodiazepine enteric-coated tablets.Comparison of efficacy,calcitonin gene-related peptide(CGRP),interleukin-17(IL-17),interleukin-10(IL-10),high mobility group box protein B1(HMGB1),Helicobacter pylori clearance.Results Compared with the control group,the study group was higher in efficacy(P<0.05).The levels of CGRP and IL-10 in the study group were higher than those in the other group(P<0.05).The levels of IL-17 and HMGB1 in the study group were lower than those in the control group(P<0.05);the clearance rate of Helicobacter pylori in the study group was higher than that in the other group(P<0.05).Conclusion In the treatment of gastric ulcer,the therapeutic effect of esomeprazole magnesium entericcoated tablets is significant and worthy of application.
作者
杨卫东
刘爱华
YANG Weidong;LIU Aihua(Tengfei Forensic Forensic Laboratory,Jingmen First People's Hospital,Jingmen Hubei 448000,China;Department of Gastroenterology,Jingmen Traditional Chinese Medicine Hospital,Jingmen Hubei 448000,China)
出处
《中国继续医学教育》
2021年第8期159-162,共4页
China Continuing Medical Education
关键词
艾司奥美拉唑镁肠溶片
奥美拉唑
幽门螺杆菌相关性胃溃疡
疗效
因子
幽门螺杆菌清除率
esomeprazole magnesium enteric-coated tablets
omeprazole
helicobacter pylori-associated gastric ulcer
efficacy
factor
helicobacter pylori clearance
