摘要
目的观察维持性血液透析(MHD)患者焦虑和抑郁的发病情况及其对炎症细胞因子白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)等指标变化的关系。方法选取2019年6月~2020年4月在中南大学湘雅医院血液净化中心治疗的85例MHD患者作为研究对象。采用抑郁自评量表(SDS)、焦虑自评量表(SAS)评估其心理状况,并按照结果分成无焦虑组和焦虑组,无抑郁组和抑郁组。比较不同焦虑、抑郁程度患者的IL-1、IL-6、CRP等指标。结果在85例MHD患者中,焦虑和抑郁障碍的发生率分别为41.1%和68.2%;焦虑组患者的IL-1、IL-6、CRP高于无焦虑组,差异有统计学意义(P<0.05);抑郁组患者的IL-1、IL-6、CRP高于无抑郁组,差异有统计学意义(P<0.05)。结论焦虑和抑郁障碍在MHD患者中的发病率较高,与患者炎症细胞因子IL-1、IL-6、CRP的表达有一定相关性。
Objective To observe the incidence of anxiety and depression in patients with maintenance hemodialysis(MHD)and the relationship between anxiety and depression and the changes of inflammatory cytokines such as interleukin-1(IL-1),interleukin-6(IL-6)and C-reactive protein(CRP).Methods A total of 85 patients with MHD who were treated in the blood purification center of Xiangya Hospital Central South University from June 2019 to April 2020 were selected as the research subjects.Self-rating depression scale(SDS)and self-rating anxiety scale(SAS)were used to evaluate their psychological status,and they were divided into non-anxiety group and anxiety group,non-depression and depression group according to the results.The levels of IL-1,IL-6 and CRP in patients with different anxiety and depression were compared.Results In 85 MHD patients,the incidence of anxiety and depression were 41.1%and 68.2%.IL-1,IL-6 and CRP in the anxiety group were higher than those in the non-anxiety group,the differences were statistically significant(P<0.05).IL-1,IL-6 and CRP in the depression group were higher than those in the non-depression group,the differences were statistically significant(P<0.05).Conclusion The incidence of anxiety and depression is higher in MHD patients with maintenance hemodialysis,which is related to the expression of inflammatory cytokines IL-1,IL-6 and CRP.
作者
胡熙苒
肖湘成
齐亮
HU Xi-ran;XIAO Xiang-cheng;QI Liang(Clinical College,Xiangtan Medical&Health Vocational College,Hu′nan Province,Xiangtan411104,China;Department of Nephrology,Xiangya Hospital Central South University,Hu′nan Province,Changsha410008,China;Department of Nephrology,Hu′nan Academy of Traditional Chinese Medicine Affiliated Hospital,Hu′nan Province,Changsha410006,China)
出处
《中国当代医药》
CAS
2021年第7期102-104,共3页
China Modern Medicine
基金
湖南省湘潭市指导性科技计划项目(ZDX-CG2019021)。
关键词
维持性血液透析
焦虑抑郁
嘌呤能离子通道型受体
炎症细胞因子
Maintenance hemodialysis
Anxiety and depression
Purinergic ion channel receptor
Inflammatory cytokines
