摘要
目的观察吉兰-巴雷综合征(GBS)患者颅内压变化的特点,GBS患者颅内压增高的相关因素。方法对1984年1月至2019年2月白求恩国际和平医院收治的328例GBS患者的临床资料及颅压的变化进行分析,对颅压增高的各种原因进行了相关分析。结果本组328例GBS患者中颅压>200mmH_(2)O 30例,发生率为9.15%,颅压180~200 mmH_(2)O 15例,发生率为4.57%,颅压80~180 mmH_(2)O 268例,发生率为81.71%,颅压60~80 mmH_(2)O 13例,发生率为3.96%,颅压40~60 mmH_(2)O 2例(年龄<3岁),发生率为0.60%,所有GBS患者无低颅压。各年龄组符合高颅压患者31例,年长儿2例颅压>180 mmH_(2)O,成人29例患者颅压>200 mmH_(2)O。发生率为9.45%。应用多因素Logistic回归分析结果显示,发病时间延长、有脑神经病变和颈抵抗是颅压的影响颅内压增高相关因素,P<0.05。结论GBS临床表现多样,病情变化复杂,部分患者出现高颅压的表现。吉兰-巴雷综合症颅内压增高与发病时间相关、伴有脑神经病变和颈抵抗临床表现的是颅内压增高的相关影响因素,对于伴有这些临床表现的GBS患者,要注意其颅压变化,从而进一步提高治疗效果。
Objective To observe the characteristics of intracranial pressure changes in patients with Guillain-Barrés syndrome(GBS),and to explore the related factors of increased intracranial pressure in patients with GBS.Methods Clinical data and changes in cranial pressure of 328 GBS patients admitted to Bethune international peace hospital were analyzed,and the causes of increased cranial pressure were analyzed.Results In 328 patients with GBS,there were 30 cases of them with cranial pressure>200 mmH_(2)O,(incidence:9.15%),15 cases of them with cranial pressure 180-200 mmH_(2)O(incidence:4.57%),268 cases of them cranial pressure 80-180 mmH_(2)O(incidence:81.71%),13 cases of them with cranial pressure 60-80 mmH_(2)O(incidence:3.96%),2 cases of them with cranial pressure 40-60 mmH_(2)O(age<3 years),and the incidence was 0.60%.All patients with GBS had no low cranial pressure.There were 31 patients with high cranial pressure in all age groups,including 2 older children with cranial pressure of>180 mmH_(2)O and 29 adults with cranial pressure of>200 mmH_(2)O.The incidence was 9.45%.The results of multivariate Logistic regression analysis showed that longer onset time cranial neuropathy and neck resistance were the related factors of increased cranial pressure(P<0.05).Conclusion The clinical manifestations of GBS are diverse,and the disease changes are complicated.Some patients show high intracranial pressure.Increased cranial pressure in GBS is associated with onset time,and cranial neuropathy and neck resistance are related to factors of increased intracranial pressure.For GBS patients with these clinical manifestations,attention should be paid to changes in cranial pressure,so as to further improve the treatment effect.
作者
王雪笠
李波
刘军
周毅
魏士贤
甄宁
Wang Xueli;Li Bo;Liu Jun;Zhou Yi;Wei Shixian;Zhen Ning(Department of Neurology,the Bethune International Peace Hospital,Shijiazhang 050082,China)
出处
《脑与神经疾病杂志》
CAS
2021年第2期89-93,共5页
Journal of Brain and Nervous Diseases
关键词
吉兰-巴雷综合征
高颅压
临床分析
Guillain-Barrés syndrome
High cranial pressure
Clinical analysis
