摘要
目的探讨骨化三醇联合贝那普利对早期老年糖尿病肾病患者尿蛋白相关指标的影响。方法选取2016年11月至2018年6月方大群众(营口)医院有限公司收治的92例早期老年糖尿病肾病患者作为研究对象,按照患者入院顺序随机分为对照组和观察组,每组46例。对照组给予贝那普利治疗,观察组采用骨化三醇联合贝那普利治疗,比较两组患者尿白蛋白排泄率、血肌酐和炎症介质水平。结果治疗后,观察组患者尿白蛋白排泄率和血肌酐水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者C反应蛋白(CRP)、白细胞介素-6(IL-6)水平低于对照组,差异有统计学意义(P<0.05)。结论骨化三醇联合贝那普利可以明显改善早期老年糖尿病肾病患者肾脏功能,同时可以减轻炎症反应。
Objective To explore the effect of calcitriol combined with benazepril on proteinuria related indexes in early elderly patients with diabetic nephropathy.Methods A total of 92 cases of early-stage diabetic nephropathy patients in Fangdaqunzhong(Yingkou)Hospital Co.,Ltd from November 2016 to June 2018 were selected as the research objects.According to the order of admission,the patients were randomly divided into a control group and an observation group,with 46 cases in each group.The control group was treated with benazepril,and the observation group was treated with calcitriol combined with benazepril.The urinary albumin excretion rate,serum creatinine and levels of inflammatory mediators were compared between the 2 groups.Results After treatment,the urinary albumin excretion rate and blood creatinine level of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05);after treatment,the levels of C-reactive protein(CRP)and interleukin-6(IL-6)in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Calcitriol combined with benazepril can significantly improve renal function and reduce inflammation in elderly patients with early-stage diabetic nephropathy.
作者
张洋
ZHANG Yang(Pharmacy Department of Fangdaqunzhong(Yingkou)Hospital Co.,Ltd.,Yingkou 115000,China)
出处
《中国药物经济学》
2021年第1期92-94,共3页
China Journal of Pharmaceutical Economics
关键词
早期
老年人
糖尿病肾病
骨化三醇
贝那普利
尿白蛋白排泄率
炎症介质
Early
Elderly
Diabetic nephropathy
Calcitriol
Benazepril
Urinary albumin excretion rate
Inflammatory mediators
