摘要
目的观察宣痹通瘀方对缺血性心肌病慢性心力衰竭患者心室重构及血脂代谢的影响。方法选取新疆医科大学第四临床医学院心血管内科收治的90例ICM慢性心力衰竭患者作为研究对象,对照组予以西医常规药物治疗,观察组在对照组治疗基础上加用宣痹通瘀方治疗。比较两组临床疗效,治疗前后单项症状积分及检测患者治疗前后心室重构指标及血脂代谢指标。结果治疗后,观察组患者的总有效率高于对照组(P<0.05);治疗后,两组患者胸闷、胸痛、心悸、眩晕、乏力、气短症状积分均明显低于治疗前(P<0.05),且观察组治疗后以上症状积分均低于对照组(P<0.05);两组患者左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白(LDL-C)均低于治疗前(P<0.05),左室射血分数(LVEF)、高密度脂蛋白(HDL-C)均高于治疗前(P<0.05),且观察组治疗后LVEDD、LVESD、TC、TG和LDL-C均低于对照组(P<0.05),LVEF、HDL-C高于对照组(P<0.05)。结论在常规西药治疗基础上采用宣痹通瘀方治疗ICM慢性心力衰竭,可明显减轻患者胸闷、胸痛等证候表现,提升临床治疗疗效,逆转患者心室重构,并能改善血脂代谢功能。
Objective To explore the effects of Xuanbi Tongyu Recipe on ventricular remodeling and serum lipid metabolism of patients with chronic heart failure(CHF)of ischemic cardiomyopathy(ICM).Methods 90 patients with CHF of ICM were enrolled.Control group was given routine western medicine treatment,while observation group was supplemented with Xuanbi Tongyu Recipe on the basis of control group.The clinical response rate and single symptom score before and after treatment were compared between the two groups.The ventricular remodeling indexes and serum lipid metabolism indexes before and after treatment were detected.Results After treatment,the total response rate of observation group was higher than that of control group(93.33%vs 77.77%)(P<0.05);symptoms integral of chest tightness,chest pain,palpitations,dizziness,fatigue and shortness of breath in both groups were significantly decreased(P<0.05),and the above scores in observation group were lower than those in control group(P<0.05);left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),total cholesterol(TC),triglyceride(TG)and low density lipoprotein(LDL-C)in both groups were decreased(P<0.05),while left ventricular ejection fraction(LVEF)and high density lipoprotein(HDL-C)were increased(P<0.05);LVEDD,LVESD,TC,TG and LDL-C in observation group were lower than those in control group(P<0.05),while LVEF and HDL-C were higher than those in control group(P<0.05).Conclusion Xuanbi Tongyu Recipe combined with routine western medicine treatment can significantly alleviate chest tightness and chest pain,improve clinical curative effect,reverse ventricular remodeling,and improve the function of serum lipid metabolism in patients with CHF of ICM.
作者
毛丽旦·阿扎提
马丽娜·阿新拜
Maolidan Azati;Marina Ashinbye(Experimental Center,School of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830011;Department of Integrated Traditional Chinese and Western Medicine,School of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830011)
出处
《湖北中医药大学学报》
2020年第6期21-24,共4页
Journal of Hubei University of Chinese Medicine
基金
新疆维吾尔自治区自然科学基金项目(项目编号:2018D01C152)。
关键词
缺血性心肌病
慢性心力衰竭
宣痹通瘀方
心室重构
血脂代谢
ischemic cardiomyopathy
chronic heart failure
Xuanbi Tongyu Recipe
ventricular remodeling
serum lipid metabolism
