摘要
目的探讨首发性精神分裂症患者的血清胱抑素C(Cys C)、肿瘤坏死因子-α(TNF-α)、脑源性神经营养因子(BDNF)水平与血脂代谢特征的关系,为精神分裂症患者的临床诊疗提供参考。方法回顾性分析本院120例首发性精神分裂症患者和90例正常人的临床资料,研究二者的血清Cys C、TNF-α、BDNF水平及总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)的水平,通过多因素Logistic回归分析考察精神分裂症患者血清Cys C、TNF-α、BDNF水平及与血脂代谢特征的相关性。结果精神分裂症组TNF-α、BDNF和Cys C平均水平分别为(33.32±7.65)ng/L、(10.56±1.32)μg/L、(0.71±0.04)mg/L,BDNF浓度较正常人群低,其余两项均高于对照组,差异均有统计学意义(P<0.05);TC、TG、LDL-C和HDL-C的平均水平分别为(4.66±0.86)mmol/L、(2.32±1.21)mmol/L、(2.57±0.45)mmol/L。异常率分别为37.5%、47.5%、50.8%和21.7%。精神分裂组血清TC、TG、LDL-C水平均较对照组高,HDL-C水平较对照组低,其中血TG、HDLC、LDL-C差异均有统计学意义(P<0.05);精神分裂症组血脂异常发生率均高于对照组,其中高TG、低HDL-C发生率差异均有统计学意义(P<0.05)。结论血液BDNF及TNF-α水平与血脂异常的发生有关。
Objective To explore the relationship between serum Cystatin C(Cys C),Tumor ne⁃crosis factor⁃α(TNF⁃α),Brain⁃derived neurotrophic factor(BDNF)levels and the characteristics of blood lipid metabolism in patients with first⁃episode schizophrenia,and to provide references for clinical diagnosis and treatment of schizophrenia.Methods To retrospectively analyze the clinical data of 120 patients with first⁃onset schizophrenia and 90 normal people in our hospital,and study their serum Cys C,TNF⁃α,BDNF lev⁃els,total cholesterol(TC),triacylglycerol(TG),The levels of low⁃density lipoprotein(LDL⁃C)and high⁃density lipoprotein(HDL⁃C).Multivariate Logistic regression analysis was used to investigate the serum Cys C,TNF⁃α,BDNF levels and their correlation with the characteristics of blood lipid metabolism in patients with schizophrenia.Results The average levels of TNF⁃α,BDNF and Cys C in the schizophrenia group were(33.32±7.65)ng/L,(10.56±1.32)μg/L,and(0.71±0.04)mg/L,respectively.The BDNF concentration was lower than that in the control population,and the other two were higher than those of the control group.The difference was statistically significant(P<0.05).The average levels of TC,TG,LDL⁃C and HDL⁃C in the schizophrenia group were(4.66±0.86)mmol/L,(2.32±1.21)mmol/L,and(2.57±0.45)mmol/L,respective⁃ly.The abnormal rate was 37.5%,47.5%,50.8%and 21.7%,respectively,which were higher than those in the control group.The blood TC,TG,LDL⁃C levels of the patient group were higher than those of the control group,and the HDL⁃C level was lower than that of the control group.The differences in blood TG,HDLC,LDL⁃C were statistically significant(P<0.05).The incidence of dyslipidemia in the schizophrenia group was all higher than that of the control group,the difference in the incidence of high TG and low HDL⁃C is statistically signifi⁃can(t P<0.05).Conclusion The blood BDNF and TNF⁃αlevels are related to the occurrence of dyslipidemia.
作者
黄凌志
王水轮
姜振东
HUANG Lingzhi;WANG Shuilun;JIANG Zhendong(Department of Psychiatry,Fifteenth Metallurgical Specialty Hospital,Huangshi,Hubei,China,435000;Department of Psychiatry,Wuhan Jimin Geriatric Hospital,Wuhan,Hubei,China,430000;Department of Psychiatry,Wuhan Wuchang Hospital,Wuhan,Hubei,China,430000)
出处
《分子诊断与治疗杂志》
2021年第2期187-190,共4页
Journal of Molecular Diagnostics and Therapy
基金
2016年度武汉市公共卫生及卫生政策科研项目(WG16E06)。
