摘要
目的:观察电针配合美多芭治疗帕金森病睡眠障碍的临床疗效。方法:选取2017年8月—2019年5月收治的帕金森病睡眠障碍患者共100例,根据随机数字表法分为联合组和西药组各50例,西药组使用口服美多芭治疗,联合组在西药组治疗方案的基础上使用电针联合治疗,2组均治疗4周为1个疗程,共治疗2个疗程。比较2组临床疗效,对2组治疗前后血清5-羟色胺(5-HT)、多巴胺(DA)及脑源性神经营养因子(BDNF)水平进行检测比较,观察治疗前后帕金森病综合评分量表(UPDRS)、帕金森睡眠量表(PDSS)、匹兹堡睡眠质量指数(PSQI)评分情况,并对2组治疗前后焦虑及抑郁情况进行比较。结果:联合组总有效率高于西药组,2组临床疗效比较,差异有统计学意义(P<0.05)。治疗后,2组5-HT、DA、BDNF水平均升高,且联合组升高程度较西药组明显,差异均有统计学意义(P<0.05);2组UPDRS、PSQI评分均降低,PDSS评分均升高,且联合组升高/降低程度较西药组明显(P<0.05);2组SAS和SDS评分明显降低,且联合组降低程度更加明显,差异均有统计学意义(P<0.05)。结论:电针联合美多芭治疗帕金森病睡眠障碍临床疗效显著,可明显改善患者血清水平和睡眠质量,缓解患者焦虑状况,其疗效优于单纯美多芭治疗。
Objective:To observe the curative effect of electroacupuncture combined with madopar for sleep disorders in Parkinson disease.Methods:A total of 100 cases of patients with sleep disorders in Parkinson disease treated from August,2017 to May,2019 were divided into the combination group and the western medicine group according to the random number table method,50 cases in each group.The western medicine group was given oral administration of madopar,and the combination group was additionally treated with electroacupuncture based on the treatment of the western medicine group.Both groups were treated for two courses,four weeks being a course.The clinical effect in the two groups was compared.Before and after treatment,the levels of 5-hydroxytryptamine(5-HT),dopamine(DA)and brain-derived neurotrophic factor(BDNF)in serum were detected and compared;the scores of Unified Parkinson Disease Rating Scale(UPDRS),Parkinson Disease Sleep Scale(PDSS)and Pittsburgh Sleep Quality Index(PSQI)were observed;the anxiety in the two groups was compared.Results:The total effective rate in the combination group was higher than that in the western medicine group,and there was significant difference being found in the comparison of the clinical effect between the two groups(P<0.05).After treatment,the levels of 5-HT,DA and BDNF in the two groups were increased,and the above changes in the combination group were more significant than those in the western medicine group,differences being significant(P<0.05);the scores of UPDRS and PSQI in the two groups were decreased,and the PDSS scores were increased,and the above changes in the combination group were more significant than those in the western medicine group(P<0.05);the scores of SAS and SDS in the two groups were significantly decreased,and the decrease in the combination group was more significant,differences being significant(P<0.05).Conclusion:The therapy of electroacupuncture combined with madopar has significant clinical effect in treating sleep disorders in Parkinson disease,and can significantly improve serum levels and sleep quality and relieve the anxiety of patients,whose curative effect is better than that of simple madopar.
作者
李磊
田壮伟
张欣
LI Lei;TIAN Zhuangwei;ZHANG Xin(不详)
出处
《新中医》
CAS
2021年第1期113-116,共4页
New Chinese Medicine
关键词
帕金森病
睡眠障碍
电针
美多芭
5-羟色胺
多巴胺
脑源性神经营养因子
帕金森睡眠量表
Parkinson disease
Sleep disorders
Electroacupuncture
Madopar
5-hydroxytryptamine
Dopamine
Brain-derived neurotrophic factor
Parkinson Disease Sleep Scale
