摘要
目的探究在砷污染的山西内蒙地区吸烟、饮酒等因素是否增加砷中毒发病风险及影响砷甲基化的代谢。方法2017年8月至2017年10月对848位受试者进行了问卷调查和尿样检测,通过描述性分析,以探究砷中毒危险因素及吸烟饮酒对砷甲基化代谢的影响。结果砷中毒患者161人,占18.99%;多因素logistic回归分析结果表明,年龄、性别、饮酒及尿tAs均是砷中毒发生的危险因素(P<0.001);男性饮酒群体的MMA%显著高于非饮酒群体,DMA%及SMR均显著低于非饮酒群体(P<0.05)。结论饮酒可增加砷中毒的发病风险,并可影响个体对砷的甲基化代谢能力。改变生活习惯,戒酒可作为砷暴露地区居民降低砷中毒发病风险的可行措施。
Objective To investigate whether factors such as smoking and drinking in the Inner Mongolia area of Shanxi contaminated by arsenic increase the risk of arsenic poisoning and the factors that affect arsenic methylation metabolism.Methods Questionnaire survey and urine test were conducted on 1008 subjects.Through descriptive analysis,the risk factors of arsenic poisoning and the influence of each factor on arsenic methylation metabolism were explored.Results There were 163 patients with arsenic poisoning,accounting for 16.2%;the results of multivariate logistic regression analysis showed that age,sex,drinking and urine tAs were all risk factors for arsenic poisoning(P<0.001);the MMA%of male smoking population was significantly higher In non-smokers,SMR was significantly lower than non-smokers(P<0.05);the MMA%of male drinking groups was significantly higher than that of non-drinking groups,and DMA%and SMR were significantly lower than non-drinking groups(P<0.05).Conclusion Both smoking and drinking can increase the risk of arsenic poisoning,and can affect the individual’s ability to metabolize arsenic methylation.Changing living habits and quitting smoking and drinking can be a feasible measure for residents in arsenic-exposed areas to reduce the risk of arsenic poisoning.
作者
尉玉婷
陈峣
刘旭丹
王欢欢
袁野
周倩倩
方方
李昕
WEI Yu-ting;CHEN Yao;LIU Xu-dan;WANG Huan-huan;YUAN Ye;ZHOU Qian-qian;FANG Fang;LI Xin(China Medical University,Shenyan,Liaoning,110122,China)
出处
《中国地方病防治》
CAS
2021年第1期11-13,共3页
Chinese Journal of Control of Endemic Diseases
基金
国家自然科学基金项目(81372933)。
关键词
砷中毒
甲基化
吸烟
饮酒
Arsenic poisoning
Methylation
Smoking
Drinking
