摘要
目的分析脑梗死病人并发血管性痴呆的危险因素,并探讨血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)水平对血管性痴呆发生的预测价值。方法选取2016年2月—2018年6月在成都市第六人民医院接受治疗的150例脑梗死病人为研究对象,分析脑梗死并发血管性痴呆的危险因素,分析VEGF、MMP-9对脑梗死后并发血管性痴呆的预测价值。结果150例就诊的脑梗死病人中,合并血管性痴呆者30例,血管性痴呆发生率为20%;有吸烟史、饮酒史、糖尿病史、高VEGF水平和高MMP-9水平脑梗死病人血管性痴呆的发生率较高(P<0.05)。Logistic回归分析结果显示,糖尿病、VEGF、MMP-9水平是脑梗死发生血管性痴呆的危险因素(P<0.05);ROC曲线分析显示:VEGF、MMP-9对脑梗死后并发血管性痴呆均有较高的预测价值(AUC>0.7),且VEGF预测的AUC、约登指数、灵敏度、特异度均高于MMP-9。结论糖尿病、高VEGF水平和高MMP-9水平是影响脑梗死病人并发血管性痴呆的危险因素,且VEGF、MMP-9水平对血管性痴呆有较好的预测价值。
Objective To analyze the influencing factors of vascular dementia in patients with cerebral infarction,and to observe the predictive value of vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)levels on the occurrence of vascular dementia.Methods The patients with cerebral infarction who were treated in the Sixth People′s Hospital of Chengdu from February 2016 to June 2018 were selected as the research objects.The difference in the incidence of vascular dementia in patients with different characteristics of cerebral infarction was compared,and the predictive value of VEGF and MMP-9 for vascular dementia after cerebral infarction was analyzed.Results Among the 150 patients with cerebral infarction,30 patients were complicated with vascular dementia.The incidence of vascular dementia was 20%.The incidence of vascular dementia in cerebral infarction patients with a history of smoking,accohol drinking,diabetes,high VEGF,and high MMP-9 levels is relatively high(P<0.05).Logistic regression analysis showed that diabetes,VEGF,and MMP-9 levels were risk factors for vascular dementia in patients with cerebral infarction.ROC curve showed that both VEGF and MMP-9 had high predictive value for vascular dementia after cerebral infarction(AUC>0.7),and the predicted AUC,Youden index,sensitivity,and specificity of VEGF were higher than those of MMP-9.Conclusion Diabetes,high VEGF level,and high MMP-9 level are risk factors affecting vascular dementia in patients with cerebral infarction,and VEGF and MMP-9 levels have better predictive value for vascular dementia.
作者
李光宗
李靖
朱晨
郑洪佳
康婕
张月辉
LI Guangzong;LI Jing;ZHU Chen;ZHENG Hongjia;KANG Jie;ZHANG Yuehui(The Sixth People′s Hospital of Chengdu,Chengdu 610051,Sichuan,China)
出处
《中西医结合心脑血管病杂志》
2021年第5期836-839,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
脑梗死
血管性痴呆
血管内皮生长因子
基质金属蛋白酶-9
危险因素
cerebral infarction
vascular dementia
vascular endothelial growth factor
matrix metalloproteinase-9
risk factors
