摘要
目的:研究不同治疗方案对妊娠期亚临床甲减(SCH)妊娠结局的影响,并探讨甲状腺过氧化物酶抗体(TPOAb)水平差异对患者发生不良妊娠结局的影响。方法:选择2017年10月-2019年10月在邵阳学院附属第二医院产科门诊建档并定期产检的孕妇,根据甲状腺功能检测选择SCH患者(试验组)124例,随机分为治疗组和随访组;并根据患者TPOAb水平,分为TPOAb(+)和TPOAb(-)。同时随机选取600例甲状腺功能无异常孕妇作为对照组。分别对比分析左甲状腺素钠片(L-T4)替代治疗和TPOAb水平差异对患者发生不良妊娠结局的影响。结果:治疗组不良妊娠结局发生率为16.95%,低于随访组的35.38%,差异有统计学意义(P<0.05),与对照组(18.67%)比较差异无统计学意义(P>0.05),随访组不良妊娠结局发生率高于对照组,差异有统计学意义(P<0.05);TPOAb(+)状态下,治疗组不良妊娠结局发生率为13.33%,低于随访组的47.37%,差异有统计学意义(P<0.05);TPOAb(-)状态下,治疗组不良妊娠结局发生率为20.69%,随访组为30.43%,差异无统计学意义(P>0.05)。结论:妊娠期亚临床甲减且TPOAb(+)患者经L-T4替代治疗后可明显减少不良妊娠发生。
Objective:To study the effect of different treatment regimens on the pregnancy outcome of subclinical hypothyroidism in pregnancy,and explore the effect of thyroid peroxidase antibody(TPOAb)level difference on the adverse pregnancy outcome of patients.Method:A total of 124 pregnant women who were registered in the Department of Obstetrics of the Second Affiliated Hospital of Shaoyang College and had regular antenatal examinations from October 2017 to October 2019 were selected according to the thyroid function test(the experimental group).They were randomly divided into the treatment group and the followup group,and according to the level of TPOAb,they were divided into TPOAb(+)and TPOAb(-).At the same time,600 pregnant women without abnormal thyroid function were randomly selected as the control group.The effects of Levothyroxine Sodium Tablet(L-T4)replacement therapy and TPOAb level difference on adverse pregnancy outcomes were compared and analyzed respectively.Result:The incidence of adverse pregnancy outcomes in the treatment group was 16.95%,lower than 35.38%in the follow-up group,the difference was statistically significant(P<0.05),there was no statistical significance compared with 18.67%in the control group(P>0.05),the incidence of adverse pregnancy outcomes in the follow-up group was higher than that in the control group,the difference was statistically significant(P<0.05).Under TPOAb(+)condition,the incidence of adverse pregnancy outcomes in the treatment group was 13.33%,which was lower than 47.37%in the follow-up group,the difference was statistically significant(P<0.05),under TPOAb(-)condition,the incidence of adverse pregnancy outcomes was 20.69%in the treatment group and 30.43%in the follow-up group,with no statistically significant difference(P>0.05).Conclusion:L-T4 replacement therapy can significantly reduce the incidence of adverse pregnancy in patients with subclinical hypothyroidism and TPOAb(+).
作者
李洲成
彭菲
向元楚
黄艳春
刘玉平
费明珠
姚辉
LI Zhoucheng;PENG Fei;XIANG Yuanchu;HUANG Yanchun;LIU Yuping;FEI Mingzhu;YAO Hui(The Second Affiliated Hospital of Shaoyang College,Shaoyang 422000,China)
出处
《中外医学研究》
2021年第5期4-6,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
湖南省教育厅科学研究项目(18A393)。
