摘要
以5-氨基-6-氟异吲哚啉-1,3-二酮为原料,通过还原、Boc保护,两步反应合成得到5-氨基-6-氟异吲哚啉-2-羧酸叔丁酯。对合成工艺进行了研究,在最佳条件下,两步反应总收率54.7%。产物结构经^(1)H NMR、^(13)C NMR和电喷雾离子源质谱(ESI-MS)表征。
Tert-butyl 5-amino-6-fluoroisoindoline-2-carboxylate was synthesized from 5-amino-6-fluoroisoindoline-1,3-dione through a two-step reaction with a total yield of 54.7%, involving reduction and Boc-protected reaction. The optimal reaction conditions were also investigated. The structure of the product was confirmed by ^(1)H NMR, ^(13)C NMR and electrospray ion source mass spectrometry(ESI-MS).
作者
高县茹
方芙容
李华梅
任习泉
万闽歌
刘斌
Gao Xianru;Fang Furong;Li Huamei;Ren Xiquan;Wan Minge;Liu Bin(School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Xi'an,Shaanxi 712046,China)
出处
《化学世界》
CAS
2021年第2期101-104,共4页
Chemical World
基金
2019年陕西省大学生创新创业(No.S201913123007)
陕西省教育厅专项科研(No.18JK0954)
陕西省中药绿色制造技术协同创新中心重点培育(No.2019XT-1-05)
陕西国际商贸学院“中药药效物质研究”创新团队(No.SSY18TD01)资助项目。
