妊娠期TPO-Ab阳性亚临床甲状腺功能减退症对妊娠结局的影响被引量：23

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摘要甲状腺激素是胚胎期胎儿大脑发育所必需。妊娠期亚临床甲状腺功能减退症(简称:亚甲减)可能导致流产、早产、胎盘早剥、低出生体重儿、妊娠期糖尿病等不良妊娠结局,重度亚甲减患者发展为甲状腺功能减退症的风险较高。甲状腺过氧化酶抗体(TPO-Ab)是反映自身免疫性甲状腺疾病的特异指标,通过激活补体、抗体依赖细胞介导的细胞毒性作用和致敏T细胞杀伤作用引起甲状腺滤泡损伤,是亚甲减病因分析和预后评估的重要指标。TPO-Ab阳性是妊娠期亚甲减的一种常见类型,现就妊娠期TPO-Ab阳性亚甲减对妊娠结局的影响进行综述。

作者杨雨溪刘瑞霞阴赪宏

机构地区首都医科大学附属北京妇产医院内科

出处《中国妇产科临床杂志》 CSCD 2021年第1期108-110,共3页 Chinese Journal of Clinical Obstetrics and Gynecology

基金首都临床特色应用研究(Z181100001718076)。

关键词妊娠期亚临床甲状腺功能减退症甲状腺过氧化物酶抗体流产早产

分类号 R714.256 [医药卫生—妇产科学]

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1瞿晓娴,应豪.甲状腺自身抗体的临床意义及应对策略[J].实用妇产科杂志,2015,31(12):890-893. 被引量：16
2董玥,王秀民.甲状腺功能减退症对妊娠期糖尿病影响的研究[J].中国妇幼健康研究,2016,27(7):834-837. 被引量：24

二级参考文献20

1Du Q, Zhu H, Yao L. Thyroid funct:ion : comparison of women in late pregnancy with control women of reproductive age in regions of dietary iodine excess [ J ]. Asia Pac J Public Health ,2013,25 (d) : s36 - sd-2.
2Ekinci EI,Chiu WL,Lu ZX,et al. A longitudinal study of thyroid au- toantibodies in pregnancy:the importance of test timing[ J ]. Clin En- docrinol(Oxf) ,2015,82(4) :604 -610.
3Alex Stagnaro-Green, Marcos Abalovich, Erik Alexander, et al. Guide- lines of the American Thyroid Association for the diagnosis and man- agement of thyroid disease during pregnancy and postpartum[ J]. Thy- roid,2011,21 (10) : 1081 - 1125.
4Nizard J, Guettrot-Imbert G, Plu-Bureau G, et al. Chronic maternal diseases and pregnancy losses. French guidelines [ J ]. J Gynecol Ob- stet Biol Reprod(Paris) ,2014,43 (10) :865 - 882.
5Twig G, Shina A, Amital H, et al. Pathogenesis of infertility and recur- rent pregnancy loss in thyroid autoimmunity [ J ]. J Autoimmun ,2012, 38(2 -3) :j275 - j281.
6Bhattacharyya R, Mnkherjee K, Das A, et al. Anti-thyroid peroxidase antibody positivity during early pregnancy is associated with pregnan- cy complications and maternal morbidity in later life [ J ]. J Nat Sci Bi- ol Med,2015,6(2) :402 -405.
7Korevaar TI, Schalekamp-Timmermans S, De Rijke YB, et al. Hypot- hyroxinemia and TPO-antibody positivity are risk factors for premature delivery : the generation R study [ J ]- J Clin Endoerinol Metab,2013, 98( 11 ) :4382 -4390.
8Chen LM, Zhang Q, Si GX, et al. Associations between thyroid au- toantibody status and abnormal pregnancy outcomes in euthyroid women [ J ]. Endocrine, 2015,48 ( 3 ) : 924 - 928.
9Matthews DC, Syed AA. The role of TSH receptor antibodies in the management of Graves' disease [ J] . Eur J Intern Med, 2011 , 22 ( 3 ) : 213 -216.
10Kern Pessoa V N, Rodacki M, Negrato C A, et al. Changes in lipid profile after treatment of women with gestational diabetes mellitus [ J]. J Clin Lipidol,2016,10(2) :350-355.