摘要
目的探讨缺铁性贫血(iron deficiency anemia,IDA)青少年女性维生素D缺乏症(Vitamin D deficiency,VDD)发生率及其与铁代谢指标的相关性。方法选择2019年1月至2019年12月来连云港市第一人民医院门诊就诊的80例青少年女性作为研究对象。其中,IDA确诊50例(IDA组,n=50),另外30例为健康女性(对照组,n=30)。分析IDA青少年女性中VDD的发生率。比较IDA组和对照组患者血清铁、血清铁蛋白、总铁结合力(total iron binding capacity,TIBC)等铁代谢指标以及维生素D水平差异;比较IDA患者中不同维生素D水平下铁代谢指标水平差异;采用Pearson’s相关性分析IDA患者中维生素D水平与铁代谢指标的相关性。结果IDA组和对照组患者在体质量指数(Body mass index,BMI)、血红蛋白、平均红细胞体积(mean corpuscular volume,MCV)、红细胞比容、血清铁、血清铁蛋白、TIBC、血清维生素D方面差异有统计学意义(t=2.096,P=0.039;t=11.856,P<0.001;t=7.591,P<0.001;t=4.194,P<0.001;t=12.492,P<0.001;t=12.572,P<0.001;t=3.152,P=0.002;t=3.626,P=0.001)。IDA组VDD患者21例(42%),对照组VDD患者5例(16.67%),两组比较差异有统计学意义(χ^(2)=5.485,P=0.019)。Pearson’s相关性分析结果显示,IDA患者中维生素D水平与血清铁、血清铁蛋白、TIBC无相关性(r=-0.081,P=0.658;r=0.029,P=0.883;r=0.141,P=0.394)。IDA患者中维生素D<30nmol/L组和维生素D>30nmol/L组在TIBC、血清维生素D方面差异有统计学意义(t=2.244,P=0.029;t=12.993,P<0.001)。结论VDD在患有IDA的青少年女性中的发生率高于健康对照组。然而,维生素D水平与铁代谢指标无显著相关性。
Objective To investigate the incidence of vitamin D deficiency(VDD)in female adolescents with iron deficiency anemia(IDA)and the correlation of VDD with iron metabolism.Methods A total of 80 female adolescents admitted to the Outpatient Department of Lianyungang First People’s Hospital in the period from Jan.2019 to Dec.2019 were enrolled in this study.Among them,50 IDA cases were assigned as the IDA group,and 30 healthy women were recruited as the control group.The incidence of VDD was analyzed in IDA group.The iron metabolism indexes including serum iron,serum ferritin and total iron binding capacity(TIBC)as well as serum vitamin D levels were compared between the two groups.The iron metabolism indexes were also compared in IDA group with different serum vitamin D levels.The correlation between serum vitamin D level and iron metabolism indexes in IDA group was analyzed by Pearson’s correlation.Results There were significant differences in body mass index(BMI),hemoglobin,mean corpuscular volume(MCV),hematocrit,serum iron,serum ferritin,TIBC and serum vitamin D between IDA group and control group(t=2.096,P=0.039;t=11.856,P<0.001;t=7.591,P<0.001;t=4.194,P<0.001;t=12.492,P<0.001;t=12.572,P<0.001;t=3.152,P=0.002;t=3.626,P=0.001).There were 21 cases(42%)and 5 cases(16.67%)of VDD in IDA group and control group respectively(χ^(2)=5.485,P=0.019).Pearson’s correlation analysis showed that there were no correlations between serum vitamin D level and serum ferritin,TIBC(r=-0.081,P=0.658;r=0.029,P=0.883;r=0.141,P=0.394).In IDA group,TIBC and serum vitamin D were significantly different between patients with vitamin D<30 nmol/L and those with vitamin D>30 nmol/L(t=2.244,P=0.029;t=12.993,P<0.001).Conclusion The incidence of VDD in female adolescents with IDA was higher than that in healthy controls.However,serum vitamin D level had no significant correlation with iron metabolism indexes.
作者
孙嘉遥
朱学涛
SUN Jia-yao;ZHU Xue-tao(Department of Laboratory Medicine,Lianyungang First People's Hospital,Lianyungang 222061,China)
出处
《中国血液净化》
CSCD
2021年第1期30-33,共4页
Chinese Journal of Blood Purification
关键词
缺铁性贫血
维生素D缺乏症
青少年
女性
铁代谢
Iron deficiency anemia
Vitamin D deficiency
Adolescent
Female
Iron metabolism
