摘要
目的:观察调任通督针刺法联合定坤丹对多囊卵巢综合征(PCOS)不孕症患者子宫内膜容受性、预后妊娠率及血液流变学的影响。方法:选取PCOS不孕症患者120例,按随机数字表法分为研究组和对照A组、对照B组各40例。对照A组采取常规促排卵治疗,对照B组在对照A组基础上予以定坤丹治疗,研究组在对照B组基础上联合调任通督针刺法治疗,均治疗3个月。比较3组治疗前后子宫内膜厚度、成熟卵泡数目、月经周期、子宫内膜容受性指标葡萄糖转运体4 (GLUT4)、整合素αvβ_(3)与血清性激素指标促卵泡激素(FSH)、黄体生成素(LH)、催乳素(PRL)及血液流变学指标。治疗后随访6个月统计3组排卵率、妊娠率。结果:治疗后,3组子宫内膜厚度、成熟卵泡数目较治疗前升高,且研究组高于对照A组、对照B组,差异均有统计学意义(P<0.05)。治疗后,3组月经周期较均较治疗前缩短,且研究组短于对照A组、对照B组,差异均有统计学意义(P<0.05)。治疗后,3组GLUT4、整合素αvβ_(3)阳性表达水平较治疗前升高,且研究组高于对照A组、对照B组,差异均有统计学意义(P<0.05)。治疗后,3组血清FSH、LH、PRL水平较治疗前降低,且研究组低于对照A组、对照B组,差异均有统计学意义(P<0.05)。治疗后,3组血浆黏度、全血低切、高切黏度较治疗前降低,且研究组低于对照A组、对照B组,差异均有统计学意义(P<0.05)。治疗后6个月,研究组排卵率为92.50%、妊娠率为32.50%,均高于对照A组、对照B组,差异均有统计学意义(P<0.05)。结论:调任通督针刺法联合定坤丹治疗PCOS不孕症患者可增加子宫内膜厚度和成熟卵泡数目,缩短月经周期,改善子宫内膜容受性及血液流变学指标,调节性激素水平,促进排卵及妊娠。
Objective:To observe the effect of acupuncture method of regulating conception vessel and governor vessel combined with Dingkun pills on endometrial receptivity, prognostic pregnancy rate and hemorheology in patients with polycystic ovarian disease syndrome(PCOS) with infertility. Methods:A total of 120 cases of PCOS patients with infertility were selected and divided into the study group, the control group A, and the control group B according to the random number table method,40 cases in each group. The control group A was treated with routine ovulation induction;the control group B was treated with Dingkun pills based on the treatment of the control group A;the study group was additionally treated with acupuncture method of regulating conception vessel and governor vessel based on the treatment of the control group B. All groups were treated for three months. Before and after treatment,the endometrial thickness,the number of mature follicles, and menstrual cycle were compared among the three groups. The indexes of endometrial receptivity including glucose transporter 4(GLUT4) and integrin αvβ_(3),the indexes of serum sex hormones including follicle-stimulating hormone(FSH), luteinizing hormone(LH) and prolactin(PRL), as well as hemorheology indexes were compared among the three groups before and after treatment. During the six-month follow-up after treatment, the ovulation rate and the pregnancy rate in the three groups were counted. Results:After treatment,the endometrial thickness and the number of mature follicles in the three groups were increased when compared with those before treatment,and the two indexes in the study group were higher than those in the control group A and the control group B,differences being significant(P<0.05).After treatment,the menstrual cycle in the three groups was shortened when compared with that before treatment,and the cycle in the study group was shorter than those in the control group A and the control group B,differences being significant(P<0.05). After treatment, the positive expression levels of GLUT4 and integrin αvβ_(3) in the three groups were increased when compared with those before treatment,and the levels in the study group were higher than those in the control group A and the control group B,differences being significant(P<0.05). After treatment,the levels of FSH,LH and PRL in serum in the three groups were decreased when compared with those before treatment,and the levels in the study group were lower than those in the control group A and the control group B,differences being significant(P<0.05). After treatment,the plasma viscosity,whole blood low shear viscosity and whole blood high shear viscosity in the three groups were decreased when compared with those before treatment,and the indexes in the study group were lower than those in the control group A and the control group B,differences being significant(P<0.05). After 6-month treatment,in the study group,the ovulation rate was 92.50%,and the pregnancy rate was 32.50%,both higher than those in the control group A and the control group B,differences being significant(P<0.05). Conclusion:For PCOS patients with infertility,the therapy of acupuncture method of regulating conception vessel and governor vessel combined with Dingkun pills can increase endometrial thickness and the number of mature follicles,shorten menstrual cycle,improve endometrial receptivity,and hemorheology indexes,regulate the levels of sex hormones,and promote ovulation and pregnancy.
作者
周浩
邵素霞
ZHOU Hao;SHAO Suxia
出处
《新中医》
CAS
2021年第2期106-111,共6页
New Chinese Medicine
关键词
多囊卵巢综合征不孕症
调任通督针刺法
定坤丹
子宫内膜容受性
妊娠率
血液流变学
Polycystic ovarian disease syndrome with infertility
Acupuncture method of regulating conception vessel and governor vessel
Dingkun pills
Endometrial receptivity
Pregnancy rate
Hemorheology
