摘要
目的探讨银杏二萜内酯葡胺注射液对急性脑卒中患者的血流指标和神经功能缺损的影响。方法选取2017年8月至2019年8月沈阳医学院附属中心医院收治的77例急性脑卒中患者为研究对象,按照治疗方法不同将患者分为对照组(32例)与观察组(45例)。对照组给予肠溶阿司匹林片+阿托伐他汀片治疗,观察组患者在对照组治疗基础上采用银杏二萜内酯葡胺注射液治疗。比较两组患者治疗前后血液流变学指标、脑部血流指标,采用美国国立卫生研究院卒中量表(NIHSS)评价两组患者治疗前后的神经功能缺损程度。结果治疗前,两组患者各项血液流变学指标比较差异无统计学意义(P>0.05);治疗后,两组患者全血还原黏度、纤维蛋白原、血浆黏度明显下降,且观察组下降程度明显优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者大脑前动脉、中动脉、后动脉以及基底动脉的血流速度比较,差异无统计学意义(P>0.05);治疗后,两组患者大脑前动脉、中动脉、后动脉以及基底动脉的血流速度较治疗前改善,但观察组患者改善程度明显好于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者NIHSS评分比较差异无统计学意义(P>0.05);治疗后,两组患者NIHSS评分降低,且观察组患者NIHSS评分低于对照组,差异有统计学意义(P<0.05)。结论使用银杏二萜内酯葡胺注射液治疗急性脑卒中患者,能改善患者的血液流变学指标,提高脑部血流速度,患者的神经功能缺损得到显著改善,疗效确切。
Objective To investigate the effect of ginkgo diterpene lactone glucomamine injection on blood flow index and neurological impairment in patients with acute stroke.Methods A total of 77 patients with acute stroke admitted to Central Hospital Affiliated to Shenyang Medical College from August 2017 to August 2019 were selected as the study subjects and were assigned into a control group(n=32)and an observation group(n=45)according to different treatment methods.The control group was given enteric aspirin tablets combined with atorvastatin tablets orally.Patients in the observation group were given ginkgo diterpene glumine injection.The indexes of hemorheology and brain blood flow before and after treatment were compared between the 2 groups.The national institutes of health stroke scale(NIHSS)was used to evaluate the degree of neurological impairment in both groups before and after treatment.Results Before treatment,there was no significant difference between the 2 groups in various indicators of hemorheology(P>0.05).After treatment,the whole blood reduced viscosity,fibrinogen and plasma viscosity of the 2 groups were significantly decreased,and the degree of decline in the observation group was significantly better than that in the control group,and the difference was statistically significant(P<0.05).Before the treatment,there was no statistically significant difference in blood flow velocity of anterior cerebral artery,middle artery,posterior artery,and basilar artery between the 2 groups(P>0.05).After treatment,the blood flow velocity indexes of the anterior cerebral artery,middle cerebral artery,posterior cerebral artery and basal artery in the 2 groups were improved compared with those before treatment,however,the improvement of the observation group was significantly better than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the NIHSS score between the 2 groups of patients(P>0.05).After treatment,the NIHSS score of the 2 groups of patients decreased,and the NIHSS score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion The treatment of acute stroke patients with ginkgo diterpene lactone meglumine injection,can reduce the patient's hemorheology index,increase blood flow to the brain.The neurological deficits are significantly improved,with obvious curative effect.
作者
张娜
ZHANG Na(The Second Department of Neurology,Central Hospital Affiliated to Shenyang Medical College,Shenyang 110024,China)
出处
《中国药物经济学》
2020年第12期83-86,共4页
China Journal of Pharmaceutical Economics
关键词
银杏二萜内酯葡胺注射液
脑卒中
血液流变学
神经功能缺损
Ginkgo diterpene lactone meglumine injection
Cerebral infarction
Hemorheology
Neurologic impairment
