摘要
目的探讨用尿碘浓度(UIC)/尿肌酐(UCr)比值评价妊娠早期妇女碘营养状况的参考区间。方法在5609名甲状腺功能正常、甲状腺自身抗体阴性、无影响甲状腺功能的疾病和药物应用史的妊娠早期妇女中,确定UIC/UCr比值的参考区间,然后在7514名妊娠早期妇女中验证该参考区间的可靠性。结果以UIC/UCr比值在75~149μg/g作为参考区间,在参考区间内,甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白(Tg)的水平均较低,整体呈现近似U型分布。甲状腺功能异常患病率、抗体阳性率和Tg>40μg/L的比例在参考区间内最低,在该区间两侧则较高。结论碘充足地区妊娠早期妇女UIC/UCr比值的参考区间为75~149μg/g,是合理的碘营养状态。
Objective To explore the reference interval of urinary iodine concentration(UIC)/urinary creatinine(UCr)ratio evaluating the iodine nutritional status in early pregnancy women.Methods A reference interval of UIC/UCr ratio was determined among 5609 early pregnant women with normal thyroid function,negative thyroid autoantibodies,and no history of diseases or taking drug that may affect thyroid function.Then we verified the reliability of this reference interval in a group of 7514 women in early pregnancy.Results We determined the UIC/UCr ratio of 75-149μg/g as the reference interval.In the reference interval,thyroglobulin antibody(TgAb),thyroid peroxidase antibody(TPOAb),and thyroglobulin(Tg)were all at lower levels,and the overall distributions were approximately U-shaped.The prevalence of thyroid dysfunction,the positive rates of antibodies and the proportion of Tg>40μg/L were the lowest within the reference interval,while higher on both sides of the interval.Conclusion The reasonable reference interval of the UIC/UCr ratio in iodine-sufficient regions is 75-149μg/g in early pregnerty women.
作者
王会如
侯源源
李嘉姝
杨阳
李咏泽
李晨嫣
滕卫平
单忠艳
Wang Huiru;Hou Yuanyuan;Li Jiashu;Yang Yang;Li Yongze;Li Chenyan;Teng Weiping;Shan Zhongyan(Department of Endocrinology and Metabolism,Institute of Endocrinology,The First Affiliated Hospital of China Medical University,Shenyang 110001,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2021年第2期114-122,共9页
Chinese Journal of Endocrinology and Metabolism
基金
"十二五"国家科技支撑计划(2014BAI06B02)。
关键词
妊娠早期
碘营养
尿碘/尿肌酐比值
尿碘
尿肌酐
Early pregnancy
Iodine nutrition
Urinary iodine concentration/urinary creatinine ratio
Urinary iodine
Urinary creatinine
