摘要
恶性脑肿瘤缺失蛋白1(deleted in malignant brain tumor protein 1,DMBT1)广泛表达于人类各组织中,其中在上皮细胞和相关腺体中表达最强。DMBT1是一种天然防御蛋白,参与先天免疫、炎症和上皮细胞分化过程,在病变过程相关的疾病中发挥着重要的作用。现通过对DMBT1在肿瘤、炎症、急性呼吸窘迫综合征(ARDS)中表达进一步综述,发现DMBT1有可能成为一种新型反映肿瘤、炎症及ARDS等疾病的临床生物标志物,希望临床医生对DMBT1有新的认识,开展临床研究进行证实,为DMBT1成为新型临床生物标志物提供新思路。
Deleten in malignant brain tumor protein 1(DMBT1) is widely expressed in various human tissues. DMBT1 is a natural defense protein with the strongest expression in epithelial cells and related glands. It is involved in innate immunity,inflammation and epithelial cell differentiation,and plays an important role in diseases related to pathological process. This article reviews the expression of DMBT1 in cancer,inflammation and acute respiratory distress syndrome(ARDS). It is found that DMBT1 may become a new clinical biomarker of cancer,inflammation,ARDS and other diseases,and it is hoped that clinicians should have a new understanding of DMBT1 and carry out clinical studies to confirm it,and provide a new idea for DMBT1 to become a new clinical biomarker.
作者
贾红炜
杨志伟
侯亚男
柳亚南
杜全胜
Jia Hong-wei;Yang Zhi-wei;Hou Ya-nan;Liu Ya-nan;Du Quan-sheng(Hebei Provincial People's Hospital Affiliated to North China University of Science and Technology,Shijiazhuang 050051,China)
出处
《中国急救医学》
CAS
CSCD
2021年第1期82-86,共5页
Chinese Journal of Critical Care Medicine
基金
博士后科研项目择优资助(B2019003039)。
