摘要
A copper-catalyzed aerobic oxidative ring expansion reaction of isatins with 1,2,3,4-tetrahydroisoquinoline for the synthesis of tetra-cyclic quinazolinones has been developed.This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields with good functional group tolerance.
基金
This work was supported by the National Natural Science Foundation of China(21871226,21502160 and 21572194)
Scien-tific Research Fund of Hunan Provincial Education Department(19B564)
Hunan Provincial Natural Science Foundation of China(2020113032)
Efficient Resource Uilization,the China Postdoc-toral Science Foundation(2018M632976 and 2019T120709)
Scientific Research Fund of Xiangtan University(XDCX2020B110).
