摘要
目的了解2016年至2018年临床分离的大肠埃希菌的标本分布及常用18种抗菌药物的耐药性,为临床合理用药提供依据。方法回顾性分析2016年至2018年临床分离的1171株大肠埃希菌的标本分布及耐药性。结果分离到的1171株大肠埃希菌,主要来源于尿液41.5%,痰液18.0%,分泌物16.5%。对氨苄西林耐药率最高(77.1%),对复方新诺明、头孢唑林、头孢曲松、环丙沙星、左氧氟沙星的耐药率29.5%~44.3%,对阿米卡星、呋喃妥因、头孢替坦、妥布霉素、亚胺培南、哌拉西林/他唑巴坦耐药率较低(<7.0%),但亚胺培南出现6.2%的耐药菌株。结论2016年至2018年大肠埃希菌的耐药率总体比较稳定,耐药率较低。缩短住院治疗时间,减少侵入性检查、治疗操作和导管留置时间,加强细蔺培养和耐药监测,加强抗菌药物的应用管理,严格预防性用药,根据药敏结果针对性使用抗菌药物,防止抗菌药物的滥用,是预防和控制大肠埃希菌感染的主要措施。
Objective To investigate the distnbution of clinical isolation of E.coli from 2016 to 2018 and the drug resistance to 18 commonly used antibiotics,so as to provide evidence for rational drug use.Methods The distribution and drug resistance of 1171 strains of E.coli were isolated from 2016 to 2018 were analyzed retrospectively.Results 1171 strains ofE.coli were isolated from urine(41.5%),sputum(18.0%)and secretion(16.5%).The resistance rate to ampicillin was 77.1%,and the resistance rate to Trimethoprim/sulfamethoxazole,Cefazolin,ceftriaxone,Ciprofloxacin,Levofloxacin was 29.5%-44.3%,the resistance rate to Amikacin,Nitrofurantoin,Cefotetan,Tobramycin,Imipenem,Piperacillin/Tazobctam was less than 7.0%.But Imipenem showed 6.2%resistance.Conclusion The main measures to prevent and control E.coli infection are to shorten the hospitalization time,reduce the invasive examination,treatment operation and catheter indwelling time,strengthen the bacterial culture and drug resistance monitoring,strengthen the application management of antibacterial drugs,strictly prevent the use of antibiotics according to the drug sensitivity results,and prevent the abuse of antibiotics.
出处
《浙江临床医学》
2021年第3期412-413,共2页
Zhejiang Clinical Medical Journal
基金
浙江省衢州市科技局科技立项项目(2015119)
常山县科技局科技立项项目(20150083)。
关键词
大肠埃希菌
耐药性
标本分布
抗菌药物
分析
E.coli
Drug Resistance
Specimen Distribution
Antibiotics
Analysis
