摘要
目的:探讨阿替普酶在急性脑梗死(ACI)治疗中对血清氧化应激、血管内皮功能和脑神经功能的影响。方法:选取2018年9月至2020年9月我院160例ACI患者,根据抽签法进行分组,对照组(n=80)给予常规阿司匹林、氯吡格雷等治疗,观察组(n=80)在对照组治疗基础上予以阿替普酶治疗,比较两组治疗效果,治疗前后血清氧化应激、血管内皮功能和脑神经功能指标水平,以及不良反应。结果:观察组疗效总有效率95.00%高于对照组的83.75%(P<0.05)。治疗后,两组丙二醛(MDA)、内皮素(ET-1)水平和美国国立卫生院卒中量表(NIHSS)评分均下降(P<0.05),超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)水平和mRS评分均升高(P<0.05),且观察组治疗前后MDA、ET-1、SOD和VEGF水平差值及NIHSS、mRS评分差值均大于对照组(P<0.05)。两组不良反应发生率无显著差异(8.75%vs6.25%)(P>0.05)。结论:阿替普酶可以减轻ACI患者氧化应激反应和血管内皮损伤,改善脑神经功能。
Objective:To investigate the effect of alteplase on serum oxidative stress,vascular endothelial function and brain nerve function in patients with acute cerebral infarction(ACI).Methods:Between September 2018 and September 2020,160 patients with ACI were selected and randomly divided into 2 groups.The control group(n=80)underwent conventional treatment with aspirin and clopidogrel,while the observation group(n=80)underwent alteplase on the basis of the treatment for the control group.The 2 groups were compared with respect to treatment effects,serum oxidative stress,vascular endothelial function and cerebral nerve function indexes as well as adverse reactions.Results:The total response rate in the observation group was 95.00%,higher than 83.75%in the control group(P<0.05).After treatment,the levels of malondialdehyde(MDA)and endothelin(ET-1)and the National Institutes of Health Stroke Scale(NIHSS)were reduced,while the levels of superoxide dismutase(SOD)and vascular endothelial growth factor(VEGF)and mRS scores were increased in the two groups(P<0.05).In addition,the difference values of MDA,ET-1,SOD and VEGF levels,NIHSS and mRS scores before and after treatment were greater in the observation group than in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(8.75%vs 6.25%)(P>0.05).Conclusion:In sum,alteplase can reduce oxidative stress and vascular endothelial damage,and improve cerebral nerve function in patients with ACI.
作者
寇新慧
吴瑞鹏
陈淼
闫立华
王芳磊
KOU Xinhui(Zhangye People's Hospital,Hexi University,Gansu Zhangye 734000,China)
出处
《河北医学》
CAS
2021年第3期503-507,共5页
Hebei Medicine
基金
甘肃省自然科学基金,(编号:20JR10RG302)。
关键词
急性脑梗死
阿替普酶
氧化应激
血管内皮功能
脑神经功能
Acute cerebral infarction
Alteplase
Oxidative stress
Vascular endothelial function
Cerebral nerve function
