摘要
目的观察舒更葡糖对颅内动脉瘤栓塞术麻醉恢复质量的影响。方法回顾性收集60例行颅内动脉瘤介入栓塞术全麻患者资料,按是否使用舒更葡糖分为2组,观察组(导管鞘拔除后给予舒更葡糖钠2 mg·kg-1)26例,对照组(导管鞘拔除后给予新斯的明1 mg+阿托品0.5 mg)34例,2组麻醉诱导和维持方法相同。比较2组一般情况,术中生命体征、手术时间、罗库溴铵用量、出入量,自主呼吸恢复时间、睁眼时间,术后CT检查陪同率、住院时间及费用等。结果术前合并症、Hunt-Hess分级、瘤体直径等组间比较均无显著差异(P> 0.05),术中各观察时点心率、平均动脉压和脉搏氧饱和度差异也均无显著意义(P> 0.05)。手术和麻醉时间、术中罗库溴铵用量和出入量、未拔管例数组间比较均无显著差异(P> 0.05),观察组术毕至出室、自主呼吸恢复、睁眼、拔管时间均短于对照组(P <0.05)。观察组术后CT检查陪同率及改良Rankin量表评分≥3分率均低于对照组(P <0.05),住院时间及费用等组间无显著差异(P> 0.05)。结论颅内动脉瘤栓塞术全麻患者应用舒更葡糖可促进患者麻醉恢复,提高术后恢复质量。
AIM To observe the effects of sugammadex on the quality of anesthesia recovery in patients with intracranial aneurysm embolization. METHODS Clinical data of 60 patients undergoing intracranial aneurysm embolization with general anesthesia were retrospectively collected. The patients were divided into two groups according to whether they were treated with sugammadex. There were 26 patients in the observation group(sugammadex 2 mg·kg-1 after catheter sheath removal) and 34 patients in the control group(neostigmine 1 mg+ atropine 0.5 mg after catheter sheath removal). Anesthesia induction and maintenance methods were the same in the two groups. The indexes of the two groups were compared, including general conditions vital signs during operation, operative time, dosage of rocuronium, intake and output volume, recovery time of spontaneous breathing, time of eye opening, accompanying rate of postoperative CT scan, hospital stay time and cost, etc. RESULTS There were no significant differences in preoperative complications, Hunt-Hess grading, diameter of tumors, etc(P > 0.05), and no significant differences in heart rate, mean arterial pressure, and pulse oxygen saturation at each observation point during the operation(P > 0.05). There were no significant differences between the two groups in terms of operation and anesthesia time, intraoperative amount of rocuronium and the number of cases without extubation(P > 0.05). Compared with the control group, time from the end of the operation to departure of the room and time of spontaneous breathing recovery, eyes opening, and extubation was significantly shorter in the observation group(P < 0.05). The postoperative CT accompanying rate and the modified Rankin scale score ≥ 3 points rate were all lower in the observation group than those in the control group(P < 0.05). There was no significant difference in length of hospital stay time and cost(P > 0.05). CONCLUSION The application of sugammadex in general anesthesia for intracranial aneurysm embolization can promote the anesthesia recovery and improve the postoperative recovery quality.
作者
陈益君
季一勤
黄长顺
陈钢
CHEN Yi-jun;JI Yi-qin;HUANG Chang-shun;CHEN Gang(Department of Anesthesiology,Sir Run Run Shaw Hospital,School o f Medicine,Zhejiang University,Hangzhou ZHEJIANG 310020,China;Department of Anesthesiology,Ningbo First Hospital,Ningbo ZHEJIANG 315010,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2021年第2期126-129,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
舒更葡糖
颅内动脉瘤
血管内操作
栓塞术
术后恢复
sugammadex
intracranial aneurysm
endovascular procedures
embolization
postoperative recovery
